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The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes.The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy.The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
List of contents
1. Barriers of the human organism and their Achilles' heels. - 2. Recent results on the development of fetal immune system: Self, epigenetic regulation, fetal immune responses. - 3. The role of endogenous retroviruses in the formation of syncytiotrophoblast and materno-fetal barrier. - 4. Maternal-fetal infections with human viruses. - 5. The mechanism and significance of integration and vertical transmission of human herpesvirus 6 genome. - 6. Maternal-fetal transmission of HBV. - 7. Function of maternal idiotypic and anti-idiotypic antibodies as transgenerational messengers. - 8. Polarised transfer of proteins through the syncytiotrophobalst and tissue culture cell lines. - 9. Fetal and neonatal illnesses caused or influenced by maternal transplacental IgG and/or therapeutic antibodies applied during pregnancy. - 10. Maternal-fetal microchimerism and fetal-juvenile malignancies. - 11. Maternal tumours associated with and influenced by pregnancy.
Summary
The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes.
The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy.
The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.
Additional text
From the reviews:
“This volume written by virology experts reviews in addition to the maternal-fetal interaction of human viruses, with emphasis on those which influence the development and tumorigenesis in the fetus and neonate. Of interest to virologists, obstetricians, neonatologists, immunologists and oncologists. A timely text.” (Pediatric Endocrinology Reviews (PER), Vol. 10 (2), January, 2013)
Report
From the reviews:
"This volume written by virology experts reviews in addition to the maternal-fetal interaction of human viruses, with emphasis on those which influence the development and tumorigenesis in the fetus and neonate. Of interest to virologists, obstetricians, neonatologists, immunologists and oncologists. A timely text." (Pediatric Endocrinology Reviews (PER), Vol. 10 (2), January, 2013)
