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Informationen zum Autor James C. Barton is Medical Director, Southern Iron Disorders Center and Clinical Professor, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Corwin Q. Edwards is Director of Graduate Medical Education, Intermountain Medical Center and LDS Hospital, Professor of Medicine, Associate Director, Internal Medicine Training Program, University of Utah School of Medicine, Salt Lake City, Utah, USA. Pradyumna D. Phatak is Head, Hematology/Medical Oncology Unit, Rochester General Hospital, Rochester, and Clinical Professor of Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA. Robert S. Britton is Associate Research Professor, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri, USA. Bruce R. Bacon is Director, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, Missouri, USA. Klappentext A guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Zusammenfassung A guide to normal iron metabolism! iron-related pathobiology! and the diagnosis and management of heritable and acquired iron overload disorders. Inhaltsverzeichnis Foreword; Preface; 1. History of iron overload disorders; 2. Normal iron absorption and metabolism; 3. Iron toxicity; 4. Tests for hemochromatosis and iron overload; 5. Complications of hemochromatosis and iron overload; 6. Insulin resistance and iron overload; 7. Infections and immunity; 8. Classical and atypical hfe hemochromatosis; 9. Heterozygosity for hfe c282y; 10. Porphyria cutanea tarda; 11. Mitochondrial mutations as modifiers of hemochromatosis; 12. Hemochromatosis associated with ferroportin gene (slc40a1) mutations; 13. Hemochromatosis associated with hemojuvelin gene (hjv) mutations; 14. Hemochromatosis associated with hepcidin gene (hamp) mutations; 15. Hemochromatosis associated with transferrin receptor-2 gene (tfr2) mutations; 16. Iron overload associated with ire mutation of ferritin heavy-chain gene (fth1); 17. Hereditary hyperferritinemia-cataract syndrome: ire mutations of ferritin light chain gene (ftl); 18. Iron overload in native Africans and African Americans; 19. Hereditary atransferrinemia; 20. Divalent metal transporter-1 (dmt1) iron overload; 21. Iron overload associated with thalassemia syndromes; 22. Iron overload associated with hemoglobinopathies; 23. Iron overload associated with pyruvate kinase deficiency; 24. Iron overload associated with congenital dyserythropoietic anemias; 25. Hereditary sideroblastic anemias; 26. Pearson marrow-pancreas syndrome; 27. Acquired sideroblastic anemias; 28. Hereditary aceruloplasminemia; 29. Friedreich ataxia and cardiomyopathy; 30. Pantothenate kinase (pank2)-associated neurodegeneration; 31. Neuroferritinopathies; 32. Gracile syndrome; 33. Neonatal hemochromatosis; 34. Iron overload due to excessive supplementation; 35. Localized iron overload; 36. Management of iron overload; 37. Population screening for hemochromatosis; 38. Ethical, legal, and social issues; 39. Directions for future research; Index....
