Aminoacyl-tRNA Synthetases in Biology and Medicine

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.

List of contents

Catalysis.- Emergence and Evolution.- Architecture.- Protein-protein Interactions and Multicomponent Complexes.- Interactions with RNAs.- Secretion and Circulation.- Regulatory Roles.- Neural Diseases.- Cancer.- Immune Diseases.- Pathologic Implications of Mitochondrial tRNA Synthetases .- Infectious Diseases.- Reprogramming of Genetic Code.- Novel functions of tRNAs.- Perspectives for Systems and Synthetic Bio-Medicine.

About the author

1983–1986 Researcher, Genetic Eng. Center, KAIST, Korea
1991–1994 Post-doc, MIT, USA
1993–1994 Senior Scientist, Cubist Pharmaceuticals, USA
1994-2001 Associate Professor, Sung Kyun Kwan University, Korea
2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ.
1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University
2008- Director, Information Center of Bio-pharmacological Network
2008- Director, Integrated Bioscience and Biotechnology Institute

Summary

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.

Product details

• Assisted by: Sunghoo Kim (Editor), Sunghoon Kim (Editor)
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 04.03.2014
• EAN: 9789401787000
• ISBN: 978-94-0-178700-0
• No. of pages: 350
• Dimensions: 165 mm x 239 mm x 24 mm
• Weight: 674 g
• Illustrations: X, 350 p.
• Series: Topics in Current Chemistry; Topics in Current Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Physical chemistry; C, biochemistry, Chemistry and Materials Science, proteins, Life sciences: general issues, Systems Biology, Biological systems, Computational and Systems Biology, MEDICINAL CHEMISTRY, Protein Science, Protein Biochemistry