Biochemistry of Pulmonary Emphysema

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

List of contents

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

Product details

• Assisted by: L. Casali (Editor), L Casali et al (Editor), C. Grassi (Editor), M. Luisetti (Editor), Travis (Editor), J Travis (Editor), J. Travis (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 08.05.2014
• EAN: 9781447137733
• ISBN: 978-1-4471-3773-3
• No. of pages: 200
• Weight: 387 g
• Illustrations: XV, 200 p. 13 illus.
• Series: Current Topics in Rehabilitation; Current Topics in Rehabilitation
• Subjects: Humanities, art, music > Psychology > Applied psychology; Natural sciences, medicine, IT, technology > Medicine > Medical professions; Non-fiction book > Psychology, esoterics, spirituality, anthroposophy > Applied psychology