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Informationen zum Autor Professor Ray Iles and Dr Suzanne Docherty, School of Health & Social Sciences, Middlesex University, Hendon Campus, London, UK. Ray Iles has experience of writing a chapter of Kumar & Clark's Clinical Medicine (one of the market leading textbooks for medical students) and would like to provide the same kind of core textbook for biomedical science students. Klappentext Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio).The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused). Zusammenfassung Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. Inhaltsverzeichnis List of Contributors xi Preface xiii Chapter 1 Anatomy and physiology of major organ systems 1 Ray K. Iles, Iona Collins and Suzanne M. Docherty 1.1 The skeletal system 1 1.2 The digestive system 6 1.3 The cardiovascular system 11 1.4 The urinary system 17 1.5 Respiratory system 21 1.6 The nervous system 23 1.7 The endocrine system 31 Bibliography 33 Chapter 2 Pathophysiology 35 Suzanne M. Docherty 2.1 Pathophysiology: a definition 35 2.2 Introduction to epidemiology 35 2.3 Introduction to pharmacology 38 2.4 Gastroenterology 44 2.5 Liver, biliary tract and pancreatic disease 50 2.6 Rheumatology 56 2.7 Urinary tract disease 59 2.8 Cardiovascular disease 65 2.9 Respiratory disease 76 2.10 Endocrine disease 80 Bibliography 88 Chapter 3 Clinical cell biology and genetics 89 Ray K. Iles and Stephen A. Butler 3.1 The cell 89 3.2 Genetics 103 3.3 Human genetic disorders 116 3.4 Important techniques in molecular cell biology 136 Bibliography 138 Chapter 4 Cellular pathology 139 Christopher M. Stonard and Jennifer H. Stonard Part I: Principles of cellular pathology 139 4.1 Structure and function of normal cells, tissues and organs 139 4.2 Tissues and organs 140 4.3 Cellular responses to injury 141 4.4 Tissue responses to injury: acute inflammation 143 4.5 Tissue responses to injury: chronic inflammation 149 4.6 Healing and repair 151 4.7 Hyperplasia and hypertrophy 154 4.8 Atherosclerosis 155 4.9 Thrombosis and embolism 157 4.10 Ischaemia and infarction 159 4.11 Amyloid and amyloidosis 160 4.12 Infections of histological importance 162 4.13 Metaplasia, dysplasia and carcinoma in situ 165 4.14 Neoplasia 168 Part II: Clinical application and laboratory techniques 175 4.15 Sampling modalities 175 4.16 Fixation 178 4.17 Specimen dissection 180 4.18 Processing and embedding 182 4.19 Microtomy 184 4.20 Standard staining methods and procedures 186 4.21 Frozen section 190 4.22 Immunohistochemistry 191 4.2...
List of contents
List of Contributors xi
Preface xiii
Chapter 1 Anatomy and physiology of major organ systems 1
Ray K. Iles, Iona Collins and Suzanne M. Docherty
1.1 The skeletal system 1
1.2 The digestive system 6
1.3 The cardiovascular system 11
1.4 The urinary system 17
1.5 Respiratory system 21
1.6 The nervous system 23
1.7 The endocrine system 31
Bibliography 33
Chapter 2 Pathophysiology 35
Suzanne M. Docherty
2.1 Pathophysiology: a definition 35
2.2 Introduction to epidemiology 35
2.3 Introduction to pharmacology 38
2.4 Gastroenterology 44
2.5 Liver, biliary tract and pancreatic disease 50
2.6 Rheumatology 56
2.7 Urinary tract disease 59
2.8 Cardiovascular disease 65
2.9 Respiratory disease 76
2.10 Endocrine disease 80
Bibliography 88
Chapter 3 Clinical cell biology and genetics 89
Ray K. Iles and Stephen A. Butler
3.1 The cell 89
3.2 Genetics 103
3.3 Human genetic disorders 116
3.4 Important techniques in molecular cell biology 136
Bibliography 138
Chapter 4 Cellular pathology 139
Christopher M. Stonard and Jennifer H. Stonard
Part I: Principles of cellular pathology 139
4.1 Structure and function of normal cells, tissues and organs 139
4.2 Tissues and organs 140
4.3 Cellular responses to injury 141
4.4 Tissue responses to injury: acute inflammation 143
4.5 Tissue responses to injury: chronic inflammation 149
4.6 Healing and repair 151
4.7 Hyperplasia and hypertrophy 154
4.8 Atherosclerosis 155
4.9 Thrombosis and embolism 157
4.10 Ischaemia and infarction 159
4.11 Amyloid and amyloidosis 160
4.12 Infections of histological importance 162
4.13 Metaplasia, dysplasia and carcinoma in situ 165
4.14 Neoplasia 168
Part II: Clinical application and laboratory techniques 175
4.15 Sampling modalities 175
4.16 Fixation 178
4.17 Specimen dissection 180
4.18 Processing and embedding 182
4.19 Microtomy 184
4.20 Standard staining methods and procedures 186
4.21 Frozen section 190
4.22 Immunohistochemistry 191
4.23 Cytopathology 196
4.24 Electron microscopy 197
4.25 In situ hybridization 201
Bibliography 203
Chapter 5 Clinical chemistry 205
Ray K. Iles and Stephen A. Butler
Introduction 205
Part I: Analytical methods 205
5.1 Sample collection 205
5.2 Analytical methods in clinical chemistry laboratories 210
5.3 Summary: common clinical tests for sample analytes 231
Part II: Clinical assessments 232
5.4 Urea and electrolytes (U and Es) 232
5.5 Metabolism and gastrointestinal markers 234
5.6 Renal function tests 236
5.7 Liver function tests 237
5.8 Heart disease and lipid disorder tests 238
5.9 Pancreatic function tests 240
5.10 Bone disease assessment 241
5.11 Endocrinological assessments 241
5.12 Pregnancy tests and pregnancy clinical chemistry 249
5.13 Therapeutic drug monitoring and toxicology 251
5.14 Clinical chemistry at the extremes of age 253
5.15 Cancer biomarkers 254
Bibliography 259
Chapter 6 Medical microbiology 261
Sarah J. Furrows and Catherine S. Fontinelle
Introduction 261
6.1 Overview of microorgan
Report
"As an accompaniment to an undergraduate programme, thisis an excellent text that manages to introduce all aspects ofbiomedical science to the reader." ( British Journalof Biomedical Science , 1 January 2013)
"Overall, Biomedical Sciences: Essential LaboratoryMedicine would make a fantastic starting textbook for biomedicalstudents. It is accessible, clinically-focused and covers allmajor relevant topics. ( Phenotype , 28 May 2012)
