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Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. I. S. H. S. VII CONTENTS CHAPTER 1 Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs Roy PICKENS, RICHARD A. MEISCH, and TRAVIS THOMPSON 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I 2. Methods of Self-Administration . . . . . . . . . . . . . . . . . . . . . . . 3 3. Establishing Drugs as Reinforcers. . . . . . . . . . . . . . . . . . . . . . 4 4. Characteristics of Self-Administration . .. . . . . . . . . . . . . . . . 7 4. 1. Ethanol. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
List of contents
1 Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs.- 1. Introduction.- 2. Methods of Self-Administration.- 3. Establishing Drugs as Reinforcers.- 4. Characteristics of Self-Administration.- 5. Drugs Not Self-Administered.- 6. Factors Influencing Self-Administration.- 7. Elimination of Self-Administration.- 8. Conclusions.- 9. References.- 2 Analgesics and Their Antagonists: Structure-Activity Relationships.- 1. Introduction.- 2. Alkaloids Derived from Opium, and Their Derivatives.- 3. Pethidines.- 4. Methadones.- 5. Miscellaneous Analgesics.- 6. Complex Morphine Derivatives: The "M" Series.- 7. Morphinans.- 8. Benzomorphans.- 9. Structure-Activity: Theory.- 10. References.- 3 Opiates: Human Psychopharmacology.- 1. Introduction.- 2. Opiate Metabolism.- 3. Behavioral and General Subjective Effects (Activating Effects, Sedating Effects, and Somatic Effects).- 4. Effects of Opiates on Mood.- 5. Pain and Analgesia.- 6. Other Pharmacological Actions of Opiates.- 7. Chronic Administration of Opiates.- 8. Classification of Opiates from Human Studies.- 9. References.- 4 Sedative-Hypnotics: Animal Pharmacology.- 1. Introduction.- 2. Axons.- 3. Synapses.- 4. Postsynaptic Membranes.- 5. Correlation of Barbiturate Anesthesia with Slow-Wave Sleep.- 6. Excitatory Actions of Barbiturates.- 7. Conclusions.- 8. References.- 5 Alcohol and Human Behavior.- 1. Alcohol: The Drug.- 2. Alcohol Abuse and Alcohol Addiction.- 3. Behavioral Effects of Alcohol.- 4. Conclusions.- 5. References.- 6 Cannabis: Structure-Activity Relationships.- 1. Introduction.- 2. Naturally Occurring Cannabinoids.- 3. Synthetic Cannabinoids.- 4. Summary and Conclusions.- 5. References.- 7 Marihuana: Human Effects.- 1. Acute Effects.- 2. Cannabis and Psychopathology.- 3. Chronic Effects.-4. References.
