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Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions.
Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
List of contents
Healing of Bone Fracture, General Concepts.- Cellular and Molecular Aspects of Bone Repair.- Primary Mineralization.- Anabolic Agents in Bone Repair.- Bone Repair in Diabetes.- Cannabinoids in Bone Repair.- Mesenchymal Stem Cells for Bone Gene Therapy.- Scaffolds in Skeletal Repair.- Bone Reaction to Implant.
About the author
Dr. Jona J. Sela, D.M.D., is H. Leslie Levine Professor of Oral Pathology and Dental Medicine, Director, Laboratory of Biomineralization, Institute of Dental Sciences, The Hebrew University Hadassah-Faculty of Dental Medicine
Dr. Itai Bab D.M.D.,
is Director, Bone Laboratory of the Institute of Dental Sciences at The Hebrew University, Jerusalem, Isreal.
Summary
Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions.
Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.
Additional text
From the reviews:
“Principles of Bone Regeneration aims to address the multidisciplinary and multifaceted nature of the modern understanding of bone healing. The volume is intended for clinicians who deal with bone disorders, the experimental skeletal biologist, or anyone with an interest in the understanding of bone healing. … it could serve as a platform for investigators to launch their own experiments or continue the efforts of others. … the book is well produced, well written, and well illustrated … .” (Ambrose Huang, Radiology, Vol. 268 (2), August, 2013)
“This 126-page book presents the foundational science and reviews the current science on the principles of bone healing. … The most appropriate audience is probably orthopedic researchers or residents-in-training who want to thoroughly understand the physiology of bone healing and how certain factors affect it. … the text is clear and efficient … . This is a concise and efficient review of the principles of bone regeneration. … for the institutional orthopedic library, it will provide an up-to-date reference on bone regeneration and healing.” (Mark R. Hutchinson, Doody’s Book Reviews, June, 2012)
Report
From the reviews:
"Principles of Bone Regeneration aims to address the multidisciplinary and multifaceted nature of the modern understanding of bone healing. The volume is intended for clinicians who deal with bone disorders, the experimental skeletal biologist, or anyone with an interest in the understanding of bone healing. ... it could serve as a platform for investigators to launch their own experiments or continue the efforts of others. ... the book is well produced, well written, and well illustrated ... ." (Ambrose Huang, Radiology, Vol. 268 (2), August, 2013)
"This 126-page book presents the foundational science and reviews the current science on the principles of bone healing. ... The most appropriate audience is probably orthopedic researchers or residents-in-training who want to thoroughly understand the physiology of bone healing and how certain factors affect it. ... the text is clear and efficient ... . This is a concise and efficient review of the principles of bone regeneration. ... for the institutional orthopedic library, it will provide an up-to-date reference on bone regeneration and healing." (Mark R. Hutchinson, Doody's Book Reviews, June, 2012)
