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The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions.
The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty.
An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries.
List of contents
C-C BOND FORMATION
Nucleophilic Addition to Aldehydes, Ketones, Carboxylic Acid Derivatives (Esters, Anhydrides) and alpha,beta-Unsaturated Carbonyl Compounds; Carbonyl Olefination
Alkylation of Aldehydes/Ketones, Carboxylic Acids, and beta-Dicarbonyl Compounds
Reactions of the Aldol and Mannich Type
Electrophilic and Nucleophilic Acylation
Reactions of Alkenes via Carbenium Ions
Transition-Metal-Catalyzed Reactions
Pericyclic Reactions
Radical Reactions
OXIDATION AND REDUCTION
Epoxidation of C=C Bonds
Dihydroxylation of C=C Bonds
Oxidation of Alcohols to Carbonyl Compounds
Enantioselective Reduction of Ketones
Biomimetic Reductive Amination
Enantioselective Wacker
HETEROCYCLIC COMPOUNDS
Three- and Four-Membered Heterocycles
Five-Membered Heterocycles
Six-Membered Heterocycles
Condensed Heterocycles
Other Heterocyclic Systems; Heterocyclic Dyes
SELECTED NATURAL PRODUCTS
Isoprenoids
Carbohydrates
Amino Acids and Peptides
Nucleotides and Oligonucleotides
DOMINO REACTIONS
Domino Reactions in Synthetic Methodology
Domino Reactions in The Synthesis of Alkaloids
Domino Reactions in The Synthesis of Isoprenoids
Domino Reactions for The Synthesis of Chromans And Dioxins
Domino Reactions in The Synthesis of Chiroptical Switches
INDEX OF REACTIONS
INDEX OF PRODUCTS
SUBJECT INDEX
About the author
Lutz Tietze studied chemistry at the universities of Freiburg and Kiel, Germany, gaining his doctorate in 1968 under Prof. Dr. B. Franck. Between 1969 and 1974 he carried out research at MIT in Cambridge, USA, and at the University of Cambridge, UK. In 1975 he gained his lecturing qualification at Münster University, taking up a professorial chair at the University of Dortmund two years later. He has been Professor and Head of the Institute for Organic Chemistry at the Georg-August-University in Göttingen since 1978.
Summary
The second edition of this classic text book has been completely revised, updated, and extended to include chapters on biomimetic amination reactions, Wacker oxidation, and useful domino reactions.
The first-class author team with long-standing experience in practical courses on organic chemistry covers a multitude of preparative procedures of reaction types and compound classes indispensable in modern organic synthesis. Throughout, the experiments are accompanied by the theoretical and mechanistic fundamentals, while the clearly structured sub-chapters provide concise background information, retrosynthetic analysis, information on isolation and purification, analytical data as well as current literature citations. Finally, in each case the synthesis is labeled with one of three levels of difficulty.
An indispensable manual for students and lecturers in chemistry, organic chemists, as well as lab technicians and chemists in the pharmaceutical and agrochemical industries.
