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Informationen zum Autor Charles Zercher earned a BA in Chemistry at Messiah College in Grantham, PA. His graduate education initiated with studies in Medicinal Chemistry at the State University of New York at Buffalo leading to an MS degree in 1985. He received a Ph.D. in Chemistry at the University of Notre Dame 1989 where he studied under the direction of Marvin Miller. Following post-doctoral studies in the laboratory of Paul Wender at Stanford University, Chuck joined the faculty at the University of New Hampshire. He was awarded the University of New Hampshire's Outstanding Assistant Professor Award in 1996 and was promoted to Professor in 2003. His teaching interests include synthetic methods and strategies, organic spectroscopy, and introductory organic chemistry. Klappentext Continuing the tradition of providing information on significant and interesting procedures with demonstrated utility in organic synthesis, this is a compilation of revised editions of Annual Volumes 80 through 84. Following precedent, there is no central theme, but the procedures can be organized into four categories: (1) asymmetric syntheses, chiral auxiliaries, and chiral ligands; (2) reactions that are promoted by metals or proceed via organometallic intermediates; (3) cycloaddition reactions; (4) valuable synthetic transformations and building blocks. This is a hands-on reference for professionals and students in organic and medicinal chemistry. Inhaltsverzeichnis Preparation of (E)-(2-Iodovinyl)Benzene from Benzyl Bromide and Diiodomethane [(E)-ß-StyrylIodide] 1 Vinylation with Inexpensive Silicon-Based Reagents: Preparation of 3-Vinylquinoline and 4-Vinylbenzophenone 7 Organolithiums and Lithium 2,2,6,6-Tetramethylpiperidide in Reductive Alkylation of Epoxides: Synthesis of (E)-Alkenes [(E)-2-Methyltetradeca-1,3-Diene] 19 2-MethylenecyclopropanecarboxylicAcidEthylEster 27 2-(2,2-Dibromoethenyl)-benzenamine 33 Stereoselective Nickel-Catalyzed 1,4-Hydroboration of 1,3-Dienes [(Z)-Dec-2-en-1-ol] 42 SynthesisofEthyl2-Ethanoyl-2-methyl-3-phenylbut-3-enoate 51 (±) trans-3,3¿ -(1,2-Cyclopropanediyl)bis-2-(E)-Propenoic Acid, Diethyl Ester: Tandem Oxidation Procedure (Top) Using Mno 2 Oxidation-Stabilized Phosphorane Trapping 57 Stereoselective Synthesis of 3-Arylacrylates by Copper-Catalyzed Syn Hydroarylation [(E)-Methyl 3-phenyloct-2-enoate] 67 Tandem Nucleophilic Addition/Fragmentation of Vinylogous Acyl Triflates:2-Methyl-2-(1-oxo-5-heptynyl)-1,3-dithiane 72 Synthesis of Ynamides by Copper-Mediated Coupling of 1,1-Dibromo-1-Alkenes with Nitrogen Nucleophiles Preparation of 4-Methyl-N-(2-Phenylethynyl)-N- (Phenylmethyl)Benzenesulfonamide 81 Synthesis of Polyynes by In Situ Desilylative Bromination and Palladium-Catalyzed Coupling: (7-(Benzyloxy)hepta-1,3,5-triynyl)triisopropylsilane 93 Preparation of a 1-Alkoxy-1-Alkyne from Reaction of a 2,2,2-Trifluoroethyl Ether with an Alkyllithium Reagent: 1-Benzyloxymethoxy-1-Hexyne 103 An Economical Synthesis of 4-Trimethylsilyl-2-butyn-1-ol 110 Single-Step Synthesis of Alkynyl Imines from N-Vinyl and N-Aryl Amides. Synthesis of N-[1-Phenyl-3-(Trimethylsilyl)-2-Propynylidene]-Benzenamine 121 Lithiated Primary Alkyl Carbamates for the Homologation of BoronicEsters 127 Synthesis of (R)-2-Methoxy-N-(1-Phenylethyl)Acetamide via DynamicKineticResolution 138 Synthesis and Resolution of Racemic trans-2-(N-Benzyl)amino-1-cyclohexanol: Enantiomer Separation by Sequential Use of (R)- and (S)-Mandelic Acid [Cyclohexanol, 2-(N-benzyl)amino, (1S,2S)- and (1R,2R)-] 147 (S a ,S)-N-[2 ¿ -(4-Methylphenylsulfonamido)-1,1á- Binaphthyl-2-yl]pyrrolidine-2-carboxamide: An OrganocatalystfortheDirectAldolReaction 157 Synthesis of (S)-8a-Methyl-3,4,8,8a-Tetrahydro-1,6-(2H,7H)- Naphthalenedione via N-Tosyl-(S a)-BINAM-L-Prolinamide Organocatalysis 16...
