Read more
Informationen zum Autor SHAYNE COX GAD , PhD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than thirty years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of forty-two books and numerous papers, presentations, and other publications. Klappentext This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development. Taking an in-depth look into novel treatments and therapeutics, the text includes chapters on hot topics like new drugs and neutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews. The coverage also presents chapters on therapeutic drug development for specific disease areas: cardiology, oncology, breast cancer, kidney diseases, and so on. Zusammenfassung This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development. Inhaltsverzeichnis PREFACE ix CONTRIBUTORS xi PART I FUNDAMENTAL CONCEPTS 1 1. Current Needs for New Therapeutic Agents and Discovery Strategies-A Systems Pharmacology Approach 3 Sophie C. Desbiens and David H. Farb 2. Target Selection in Drug Discovery 25 Charles F. Albright 3. New Drug Applications 35 John S. McInnes and Donald O. Beers 4. From Concept to the Clinics: Development of Cancer Therapeutics 47 Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary 5. Development of Countermeasures for Bioterrorism in the United States 73 Gregory H. Levine and Jeffrey I. Handwerker 6. Development and Application of Conformation-Selective Integrin Antibodies 91 Nathan S. Astrof, Dan Peer, and Motomu Shimaoka 7. Pain Management Market Overview 113 Anita Holdcroft 8. Antiviral Market Overview 127 Anita Arora, Natalia Mendoza, and Stephen K. Tyring PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145 9. High-Throughput Screening for Small-Molecule Drug Discovery 147 C. Parker and J.-H. Zhang 10. Mass Spectrometry 181 Robert D. English and Anthony M. Haag 11. Molecular Screening for Therapeutic Agents 207 R. Damoiseaux 12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241 Zhengdong Cheng 13. Development of Antimicrobial Peptides as Therapeutic Agents 285 Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant 14. Antibodies for Human Diseases 359 Guo-Liang Yu and Jian Ni 15. Combinatorial Compounds and Drug Discovery 399 James C. Bigelow 16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413 David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim 17. RNAi-Mediated Therapeutics 425 Nuria Morral and Scott R. Witting 18. Crystallography 445 Carl H. Schwalbe 19. PEGylation 463 Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal 20. Gold Standard Animal Models 517 Carol Casteneda and Michael S. LaPointe 21. Discovery of Vaccine Adjuvants 533 Fiona A. Sharp and Ed C. Lavelle 22. Oral Delivery of Macromolecules for the Development of Therapeutic ...
