DEVELOPMENT OF THERAPEUTIC AGENTS

Informationen zum Autor SHAYNE COX GAD , PhD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than thirty years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of forty-two books and numerous papers, presentations, and other publications. Klappentext This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development. Taking an in-depth look into novel treatments and therapeutics, the text includes chapters on hot topics like new drugs and neutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews. The coverage also presents chapters on therapeutic drug development for specific disease areas: cardiology, oncology, breast cancer, kidney diseases, and so on. Zusammenfassung This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development. Inhaltsverzeichnis PREFACE ix CONTRIBUTORS xi PART I FUNDAMENTAL CONCEPTS 1 1. Current Needs for New Therapeutic Agents and Discovery Strategies-A Systems Pharmacology Approach 3 Sophie C. Desbiens and David H. Farb 2. Target Selection in Drug Discovery 25 Charles F. Albright 3. New Drug Applications 35 John S. McInnes and Donald O. Beers 4. From Concept to the Clinics: Development of Cancer Therapeutics 47 Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary 5. Development of Countermeasures for Bioterrorism in the United States 73 Gregory H. Levine and Jeffrey I. Handwerker 6. Development and Application of Conformation-Selective Integrin Antibodies 91 Nathan S. Astrof, Dan Peer, and Motomu Shimaoka 7. Pain Management Market Overview 113 Anita Holdcroft 8. Antiviral Market Overview 127 Anita Arora, Natalia Mendoza, and Stephen K. Tyring PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145 9. High-Throughput Screening for Small-Molecule Drug Discovery 147 C. Parker and J.-H. Zhang 10. Mass Spectrometry 181 Robert D. English and Anthony M. Haag 11. Molecular Screening for Therapeutic Agents 207 R. Damoiseaux 12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241 Zhengdong Cheng 13. Development of Antimicrobial Peptides as Therapeutic Agents 285 Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant 14. Antibodies for Human Diseases 359 Guo-Liang Yu and Jian Ni 15. Combinatorial Compounds and Drug Discovery 399 James C. Bigelow 16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413 David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim 17. RNAi-Mediated Therapeutics 425 Nuria Morral and Scott R. Witting 18. Crystallography 445 Carl H. Schwalbe 19. PEGylation 463 Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal 20. Gold Standard Animal Models 517 Carol Casteneda and Michael S. LaPointe 21. Discovery of Vaccine Adjuvants 533 Fiona A. Sharp and Ed C. Lavelle 22. Oral Delivery of Macromolecules for the Development of Therapeutic ...

List of contents

PREFACE ix
 
CONTRIBUTORS xi
 
PART I FUNDAMENTAL CONCEPTS 1
 
1. Current Needs for New Therapeutic Agents and Discovery Strategies--A Systems Pharmacology Approach 3
Sophie C. Desbiens and David H. Farb
 
2. Target Selection in Drug Discovery 25
Charles F. Albright
 
3. New Drug Applications 35
John S. McInnes and Donald O. Beers
 
4. From Concept to the Clinics: Development of Cancer Therapeutics 47
Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary
 
5. Development of Countermeasures for Bioterrorism in the United States 73
Gregory H. Levine and Jeffrey I. Handwerker
 
6. Development and Application of Conformation-Selective Integrin Antibodies 91
Nathan S. Astrof, Dan Peer, and Motomu Shimaoka
 
7. Pain Management Market Overview 113
Anita Holdcroft
 
8. Antiviral Market Overview 127
Anita Arora, Natalia Mendoza, and Stephen K. Tyring
 
PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145
 
9. High-Throughput Screening for Small-Molecule Drug Discovery 147
C. Parker and J.-H. Zhang
 
10. Mass Spectrometry 181
Robert D. English and Anthony M. Haag
 
11. Molecular Screening for Therapeutic Agents 207
R. Damoiseaux
 
12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241
Zhengdong Cheng
 
13. Development of Antimicrobial Peptides as Therapeutic Agents 285
Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant
 
14. Antibodies for Human Diseases 359
Guo-Liang Yu and Jian Ni
 
15. Combinatorial Compounds and Drug Discovery 399
James C. Bigelow
 
16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413
David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim
 
17. RNAi-Mediated Therapeutics 425
Nuria Morral and Scott R. Witting
 
18. Crystallography 445
Carl H. Schwalbe
 
19. PEGylation 463
Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal
 
20. Gold Standard Animal Models 517
Carol Casteneda and Michael S. LaPointe
 
21. Discovery of Vaccine Adjuvants 533
Fiona A. Sharp and Ed C. Lavelle
 
22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547
Hye J. Lee and Chanmi Choi
 
23. Aerosol Drug Delivery to the Lungs 565
Andrew R. Martin and Warren H. Finlay
 
24. Resistance to Antiplatelet Theraphy 589
Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino
 
25. Antibiotic Development 611
Robert L. Bettiker and Jason C. Gallagher
 
PART III THERAPEUTIC TOPICS 629
 
26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631
Shu Yeong Queck and Michael Otto
 
27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645
Byungse Suh and Rafi k Samuel
 
28. Anti-Inflammatory Therapeutics 655
Marion M. Chan and Dunne Fong
 
29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673
Kelly L. Brown
 
30. Cardiovascular Disease: In-Depth Look 707
Nicholas B. Norgard and Mazen Abu-Fadel
 
31. Ezetimibe and Cholesterol Absorption 723
Stefan Oswald and Werner Siegmund
 
32. Cardiology--In-Depth Look: Kinases as Therapeutic Targets in the Heart 743
Karin Mauer and J. Emilio Exaire
 
33. Statins in the Reduction of Cardiovascular Events 773
Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta
 
34. Cardiology--In-Depth Look: Advances in Antiplatelet Theraphy 785
Karin Mauer and Jorge F. Saucedo
 
35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813
Brian Hemstreet
 
36. Pharmacology of Vasopressin and the Renin-

Report

"The text is well-written and includes extensive references." ( Book News , 1 April 2012)

Product details

• Authors: SC Gad, Shayne C. Gad, Shayne Cox Gad, Shayne Cox (EDT) Gad, Shayne Cox (Ibs Gad, Gad Shayne Cox
• Assisted by: Shayn Cox Gad (Editor), Shayne Cox Gad (Editor), Shayne Cox Gad (Editor), Gad Shayne Cox (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 02.09.2011
• EAN: 9780471213857
• ISBN: 978-0-471-21385-7
• No. of pages: 680
• Series: Pharmaceutical Development; Pharmaceutical Development Series; Pharmaceutical Development Series; Pharmaceutical Development
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Miscellaneous; Chemie, Medizin, Wirkstoffforschung, chemistry, Pharmacology & Pharmaceutical Medicine, Pharmakologie u. Pharmazeutische Medizin, Wirkstoffforschung u. -entwicklung, Drug Discovery & Development, Medical Science