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Informationen zum Autor Virender K. Sharma is Professor of Chemistry as well as Director of the Center of Ferrate Excellence at Florida Institute of Technology. Dr. Sharma has organized several symposia, including "Nanotechnology and the Environment: Green Technology" at the 243rd American Chemical Society National Meeting in 2012. He is also coauthor of Mossbauer Spectroscopy: Application in Chemistry, Biology, Industry and Nanotechnology (Wiley). Klappentext Explains the role of reactive intermediates in biological systems as well as in environmental remediationWith its clear and systematic approach, this book examined the broad range of reactive intermediate that can be generated in biological environments, detailing the fundamental properties of each reactive intermediate. Readers gain a contemporary understanding of how these intermediates react with different compounds, with an emphasis on amino acids, peptides, and proteins. The author not only sets forth the basic chemistry and nature of reactive intermediates, he also demonstrates how the properties of the intermediates presented in the book compare with each other.Oxidation of Amino Acids, Peptides, and Proteins begins with a discussion of radical and non-radical reactive species as well as an exploration of the significance of reactive species in the atmosphere, disinfection processes, and environmental remediation. Next, the book covers such topics as:* Thermodynamics of amino acids and reactive species and the effect of metal-ligand binding in oxidation chemistry* Kinetics and mechanisms of reactive halogen, oxygen, nitrogen, carbon, sulfur and phosphate species as well as reactive high-valent Cr, Mn, and Fe species* Reactivity of the species with molecules of biological and environmental importance* Generation of reactive species in the laboratory for kinetics studies* Oxidation of amino acids, peptides, and proteins by permanganate, ferryl, and ferrate species* Application of reactive species in purifying water and treating wastewaterWith this book as their guide, readers will be able to assess the overall effects of reactive intermediates in biological environments. Moreover, they'll learn how to apply this knowledge for successful water purification and wastewater treatment. Zusammenfassung This book summarizes the chemical mechanisms and detailed kinetics of amino acid and peptide oxidation to help understand how proteins break down or dissociate when under stress in biological and environmental systems so that new drugs and antioxidants may be developed. Inhaltsverzeichnis PREFACE TO SERIES xiii INTRODUCTION xv 1 Reactive Species 1 1.1 Diseases 3 1.1.1 Neurodegenerative Diseases 3 1.1.1.1 Alzheimers Disease 5 1.1.1.2 Parkinson's Disease 5 1.1.2 Metals in Human Diseases 6 1.2 Protein Structure 9 1.2.1 Oxidative Labeling 10 1.2.1.1 Carbonyl Labeling 10 1.2.1.2 Cysteine Residue Labeling 10 1.2.1.3 Reactive Species Labeling 10 1.2.1.4 Hydroxyl Radical Labeling 12 1.2.2 Other Techniques 13 1.3 Reactive Species 20 1.3.1 Halogen Species 20 1.3.2 Oxygen Species 21 1.3.3 Nitrogen Species 22 1.3.4 Sulfur Species 22 1.3.5 High-Valent Cr, Mn, and Fe Species 25 1.4 Reactive Species in Environmental Processes 26 1.4.1 Atmospheric Environment 26 1.4.2 Disinfection By-Products (DBP) 27 1.4.3 Oxidation Processes for Purifying Water 29 References 30 2 Acid-Base Properties 52 2.1 Dissociation Constants 54 2.2 Speciation 62 2.2.1 Protonation 62 2.2.2 Metal Complexes 63 2.2.2.1 Iron 64 2.2.2.2 Copper, Zinc, and Nickel 66 References 69 3 Halogenated Species 78 3.1 Hypohalogens 79 3.1.1 Hypochlorite 79 3.1.1.1 Kinetics of HOCl 79
