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Informationen zum Autor Manuel Monleón Pradas is Professor at the Technical University of Valencia, Spain, where he founded and headed the Centre for Biomaterials and Tissue Engineering (1999-2009). He was Head of the Biomaterials Unit at the Centro de Investigación Príncipe Felipe (Valencia, Spain), and has been visiting professor at the University of Paris-XI. He has authored over 160 papers in the fields of polymer science and biomaterials. María J. Vicent is Head of the Polymer Therapeutics Laboratory at Centro de Investigación Príncipe Felipe (Valencia, Spain). She has expertise in several aspects of polymer therapeutics field, from synthesis of nanopharmaceutics to their biological evaluation in different cell and in vivo models. Dr. Vicent has coauthored over 70 papers and 7 patents in the field. Furthermore, in 2012, she cofounded a spin-off company named Polypeptide Therapeutic Solutions SL, Spain, based on a family patent from her own group. Klappentext Biomedical applications of Polymers from Scaffolds to Nanostructures The ability of polymers to span wide ranges of mechanical properties and morph into desired shapes makes them useful for a variety of applications, including scaffolds, self-assembling materials, and nanomedicines. With an interdisciplinary list of subjects and contributors, this book overviews the biomedical applications of polymers and focuses on the aspect of regenerative medicine. Chapters also cover fundamentals, theories, and tools for scientists to apply polymers in the following ways: - Matrix protein interactions with synthetic surfaces - Methods and materials for cell scaffolds - Complex cell-materials microenvironments in bioreactors - Polymer therapeutics as nano-sized medicines for tissue repair - Functionalized mesoporous materials for controlled delivery - Nucleic acid delivery nanocarriers Concepts include macro and nano requirements for polymers as well as future perspectives, trends, and challenges in the field. From self-assembling peptides to self-curing systems, this book presents the full therapeutic potential of novel polymeric systems and topics that are in the leading edge of technology. Zusammenfassung Biomedical applications of Polymers from Scaffolds to Nanostructures The ability of polymers to span wide ranges of mechanical properties and morph into desired shapes makes them useful for a variety of applications! including scaffolds! self-assembling materials! and nanomedicines. Inhaltsverzeichnis Preface xi Contributors xvii Part A Methods for Synthetic Extracellular Matrices and Scaffolds 1 1 Polymers as Materials for Tissue Engineering Scaffolds 3 Ana Vallés Lluch Dunia Mercedes García Cruz Jorge Luis Escobar Ivirico Cristina Martínez Ramos and Manuel Monleón Pradas 1.1 The Requirements Imposed by Application on Material Structures Intended as Tissue Engineering Scaffolds 3 1.2 Composition and Function 5 1.2.1 General Considerations 5 1.2.2 Some Families of Polymers for Tissue Engineering Scaffolds 8 1.2.3 Composite Scaffold Matrices 12 1.3 Structure and Function 14 1.3.1 General Considerations 14 1.3.2 Structuring Polymer Matrices 15 1.4 Properties of Scaffolds Relevant for Tissue Engineering Applications 24 1.4.1 Porous Architecture 24 1.4.2 Solid State Properties: Glass Transition Crystallinity 25 1.4.3 Mechanical and Structural Properties 26 1.4.4 Swelling Properties 28 1.4.5 Degradation Properties 29 1.4.6 Diffusion and Permeation 30 1.4.7 Surface Tension and Contact Angle 31 1.4.8 Biological Properties 31 1.5 Compound Multicomponent Constructs 32 1.5.1 Scaffold-Cum-Gel Constructs 32 1.5.2 Scaffolds and Membranes Containing Micropa...
