Type 1 Diabetes - Etiology and Treatment

The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets. Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.

List of contents

1 Epidemiology of Type 1 Diabetes.- 2 Genetics of Type 1 Diabetes.- 3 Prediction and Prevention of Type 1 Diabetes.- 4 Molecular Biology of ?-Cell Destruction by Autoimmune Processes.- 5 Type 1 Diabetes in Autoimmune Syndromes.- 6 The Metabolic Basis of Insulin Secretion.- 7 Prevention and Correction of Hypoglycemia: Relevance to Type 1 Diabetes.- 8 Nonautoimmune Forms of Diabetes: Neonatal Diabetes, Didmoad-Wolfram Syndrome, and Related Syndromes.- 9 Diabetic Ketoacidosis.- 10 Insulin Regimens for Type 1 Diabetes.- 11 Relationship Between Metabolic Control and Complications in Diabetes: Therapeutic Implications of the Diabetes Control and Complications Trial.- 12 Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors.- 13 Living with Diabetes: Educating the Patient and Family with Type 1 Diabetes.- 14 Nutritional Management in Type 1 Diabetes.- 15 Special Problems and Management of the Child Less Than 5 Years of Age.- 16 The Preadolescent Child with Type 1 Diabetes.- 17 The Adolescent with Type 1 Diabetes.- 18 Hypoglycemia in Type 1 Diabetes.- 19 Pregnancy and Type 1 Diabetes.- 20 Surgery for the Patient with Type 1 Diabetes.- 21 Biochemistry and Molecular Biology of Diabetic Complications.- 22 The Eye: Diabetic Retinopathy/Ophthalmopathy.- 23 The Kidney: Diabetic Nephropathy.- 24 Diabetic Peripheral and Autonomic Neuropathy.- 25 The Diabetic Foot.- 26 Atherosclerosis in Type 1 Diabetes.- 27 Cutaneous Complications of Type 1 Diabetes.- 28 Infection and Diabetes.- 29 Pancreas Transplantation.- 30 Islet Transplantation.- 31 ?-Cell Replacement Therapy for Type 1 Diabetes.- 32 Islet Growth Factors.

Summary

A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.

Additional text

"The first section provides a sound discussion of our understanding of the etiology of the disease, providing the reader with an excellent working knowledge to assess possible future prevention strategies. The clinical chapters are well organized, authored by known experts, and provide excellent summaries of cutting edge management. The final chapters devoted to islet transplantation and the relevant scientific issues are timely and enlightening...This entry in the Contemporary Endocrinology series represents a uniquely accessible overview of the current scientific and clinical frontiers relevant to type 1 diabetes mellitus. By providing an understanding of where immunological knowledge will likely lead and what current therapy should entail, this book provides an opportunity for both clinical and research specialists to better understand each other's fields." -Doody's Health Sciences Book Review Journal

"A highly recommended book that is hard to put down. It was easy to read, detailed, and extremely useful in a practical sense for clinicians." - E-Streams

"The complex interactions of genetics, autoimmunity, and insulin secretion are covered thoroughly and would gainfully challenge most experts in the field." -Annals of Internal Medicine

Report

"The first section provides a sound discussion of our understanding of the etiology of the disease, providing the reader with an excellent working knowledge to assess possible future prevention strategies. The clinical chapters are well organized, authored by known experts, and provide excellent summaries of cutting edge management. The final chapters devoted to islet transplantation and the relevant scientific issues are timely and enlightening...This entry in the Contemporary Endocrinology series represents a uniquely accessible overview of the current scientific and clinical frontiers relevant to type 1 diabetes mellitus. By providing an understanding of where immunological knowledge will likely lead and what current therapy should entail, this book provides an opportunity for both clinical and research specialists to better understand each other's fields." -Doody's Health Sciences Book Review Journal

"A highly recommended book that is hard to put down. It was easy to read, detailed, and extremely useful in a practical sense for clinicians." - E-Streams

"The complex interactions of genetics, autoimmunity, and insulin secretion are covered thoroughly and would gainfully challenge most experts in the field." -Annals of Internal Medicine

Product details

• Assisted by: Mar A Sperling (Editor), Mark A Sperling (Editor), Mark A. Sperling (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 25.10.2010
• EAN: 9781617372582
• ISBN: 978-1-61737-258-2
• No. of pages: 593
• Dimensions: 178 mm x 32 mm x 254 mm
• Weight: 1127 g
• Illustrations: XIII, 593 p. 68 illus., 7 illus. in color.
• Series: Contemporary Endocrinology; Contemporary Endocrinology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Diabetes, C, Medicine, Diseases