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Alzheimer´s Disease (AD), the most frequent cause of mental decline in the elderly represents one of the major health problems facing modern society. Despite considerable progress in the clinical diagnosis, epidemiology, structural basis, biochemistry, molecular genetics, and pharmacological aspects of AD, its etiology, molecular backgrounds, and treatment challenges are still poorly understood. This volume based on the 2nd International Symposium of EBEWE Research Initiative in October 1993 in Salzburg, Austria, is conceived as a review of our current knowledge of morphology, diagnostic clinical and imaging techniques, methodological approaches of cognitive assessment, trial designs, outcome variables and possibilities of therapy of AD and other neurodegenerative disorders. The book´s coverage is broad and it should be of interest for investigators, clinicians, and researchers involved in the problems of AD.
List of contents
Synaptic pathology in the pathogenesis of Alzheimer dementia.- Classification of dementias based on functional morphology.- Computed tomography and magnetic resonance imaging in the diagnosis of Alzheimer's disease.- Diagnostic imaging techniques with special reference to PET.- Neurochemical investigations in patients with dementia of Alzheimer type and their clinical value.- Different methodological approaches for the construction of a therapy sensitive ADL scale for the assessment of Alzheimer patients.- Trial designs and outcome variables in antidementia drug testing.- Cognitive deterioration in old age and in the course of dementia.- NGF and Alzheimer's disease: a model for trophic factor therapy in neurodegeneration.- Efficacy of Cerebrolysin® in Alzheimer's disease.
