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Informationen zum Autor NEAL F. LUE, MD, PHD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems. CHANTAL AUTEXIER, PHD, is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms. Klappentext Explores the structure, function, and emerging applications of telomerases With contributions from leading experts and pioneers in the field, this book offers a comprehensive review of telomerase structure and function in a variety of organisms, including yeasts, ciliates, plants, and mammals. Chapters provide integrated discussions that examine the connections between the chemistry, biology, and emerging clinical applications of the telomerase enzyme. In particular, readers will gain new insights into the role of telomerases in cellular senescence, aging, and cancer. Telomerases begins with an overview of the telomerase complex, followed by in-depth discussions of the chemistry of its two critical components: TERT and TER. Next, the book brings readers up to date with our current understanding of telomerases, including: Biological regulatory mechanisms that control the synthesis and assembly of the telomerase complex Regulations imposed by the nucleoprotein complex at chromosome ends Studies underscoring the role of the telomerase enzyme as a promising target and a useful tool in medical interventions The book concludes with an essay that places the telomerase enzyme in an evolutionary context, illustrating its place within the highly diverse family of reverse transcriptases. Telomerases is recommended for biochemists, enzymologists, protein scientists, cancer researchers, biophysicists, geneticists, and cell, molecular, and chromosome biologists. Explaining what the latest research in the field reveals about the structure and function of telomerases and how this research has informed investigations into their clinical applications, the book points to future avenues of research that will enable us to better understand the chemistry, biology, and clinical applications of telomerases. Zusammenfassung This book gives biochemists, geneticists, and related investigators a comprehensive and up-to-date review and evaluation of telomerase research, a key subfield in understanding genetic function and diseases. Chapters cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Inhaltsverzeichnis Preface vii Contributors ix 1 The Telomerase Complex: An Overview 1 Johanna Mancini and Chantal Autexier 2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23 Yehuda Tzfati and Julian J.-L. Chen 3 TERT Structure, Function, and Molecular Mechanisms 53 Emmanuel Skordalakes and Neal F. Lue 4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79 Tara Beattie and Pascal Chartrand 5 Transcriptional Regulation of Human Telomerase 105 Antonella Farsetti and Yu-Sheng Cong 6 Telomerase Regulation and Telomere-Length Homeostasis 135 Joachim Lingner and David Shore 7 Telomere Structure in Telomerase Regulation 157 Momchil D. Vodenicharov and Raymund J. Wellinger 8 Off-Telomere Functions of Telomerase 201 Kenkichi Masutomi and William C. Hahn 9 Mu...
