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Bioresponse-linked instrumental analysis combines biomolecular recognition, initiating a biological effect in the organism, and chemical analysis. Although this technology is only at its beginning, the power of this approach is obvious. It provides both, information on effects with respect to the applied target structures as well as the chemical structure and concentration of active substances present in a sample. In this book, examples ranging from endocrine disruptors to neurotoxic substances are used to illustrate the principle.
List of contents
1 Approaches to Bioresponse-Linked Instrumental Analysis: On-Line Coupling of Liquid Chromatography to Biological Assays.- 2 Detection of Bioeffective Environmental Compounds by High-Performance Thin Layer Chromatography.- 3 Electronic Noses.- 4 Receptors as Analytical Tools for Bioresponse - Linked Instrumental Analysis.- 5 Bioresponse-linked Analysis Based on Acetylcholinesterase Inhibition.- 6 Transport Proteins in Blood: A Possible Role in Hormone Disrupting Effects of Pollutants.- 7 Biomonitor Systems Derived from Thylakoids for the Detection of Phytotoxic Substances.- 8 Proteomics - A Tool for Bioresponse-Linked Analysis.- Conclusions and Outlook.
About the author
Professor Dr. Bertold Hock, Technische Universität München
Summary
Bioresponse-linked instrumental analysis combines biomolecular recognition, initiating a biological effect in the organism, and chemical analysis. Although this technology is only at its beginning, the power of this approach is obvious. It provides both, information on effects with respect to the applied target structures as well as the chemical structure and concentration of active substances present in a sample. In this book, examples ranging from endocrine disruptors to neurotoxic substances are used to illustrate the principle.
Foreword
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