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This book is based on lectures held at the In ternational Expert Meeting "Current Update on Psychoimmunology" (September 26-28, 1996, Graz, Austria), which was organized by "Ver ein zur Forderung der Wissenschaft und For schung an der Universitatsklinik fUr Psychia trie Graz" (Chairman: H. -G. Zapotoczky; Coor dinators: M. Lux, G. Wieselmann; Local Orga nizing Committee: E. Braun, M. Bretterklieber, H. Hausler, G. Herzog, S. Kriechbaum, S. Sper lich). The book tries to close the gap between immunological findings on one hand, psychological, psychopathological, electrophysiological and neuroimaging aspects on the other. It also deals with the issue of "cause and effect" (of immunological alternatives) in different or ganic and/or mental disorders, and emphasizes the necessity of consid ering a variety of treatment strategies. There are dynamic interactions and several important similarities between the immune system and the central nervous system, which help to lay the rational basis for "psy choimmunology". Both systems have the capacity for memory and both play vital roles in adaptation and defence. Furthermore, in each system pathological changes can occur in the event of inappropriate responses to internal or external stimuli, leading to psychiatric as well as organic illnesses and autoimmune diseases could also arise as a consequence of dysfunction and maladaptation, respectively. Finally, the editor is grateful to all the authors and experts for their contributions to the meeting and for preparing their manuscripts for this publication. Graz, November 1997 G.
List of contents
Psychoimmunology: basic research and an integrative view.- Psychoneuroimmunology and neuroendocrinology - an integrative view.- The role of the autonomous nervous system in the dialogue between the brain and immune system.- Analysis of gene expression of human brain.- New trends in neuropsychiatry: polyimmunotherapy - a new way of treatment in neurology and psychiatry. The 5S-7S Tilz protocol and the antigen clearing deficiency syndromes.- Schizophrenia: immunological measurements.- Immunological alterations in three types of schizophrenia.- Cytokine abnormalities in schizophrenia: a review of their pathogenic significance, with particular reference to the autoimmune hypothesis.- Relationship between immune and behavioral measures in schizophrenia.- Immunomodulatory effects of neuroleptics to the cytokine system and the cellular immune system in schizophrenia.- Cytokines in schizophrenia. Results from a longitudinal study.- Immunological aspects in mental disorders and Alzheimer's disease.- Psychoimmunology, anxiety disorders and TMJ-disorders.- Immunological alterations and neuropsychiatric symptoms: antimicroglia antibodies and psychopathological subgroups in Alzheimer's disease.- Platelet antibodies in mental disorder.- Plasma levels of interleukin 1? and interleukin 6 in mental disorders.- Electrobiophysiological and neuroimaging aspects.- Effects of cytokines on human EEG and sleep.- Role of cingulate gyrus during Wisconsin card sorting test: a single photon emission computed tomography (SPECT) study.
