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This book comprises the proceedings of an view of the subject to an audience of clinicians. Advanced Teaching Course held in Rotterdam, The outcome is the present book. Due to the ex The Netherlands, on November 25-26, 1976. pert knowledge and didactic capacity of the con The history of this Course goes back to tributors, we hope the book will be of some use in 1972, when a small, loosely connected group of making research views accessible to those Dutch researchers, who were fascinated by in engaged in clinical practice. vestigating fundamental problems of inflam In organizing this Course we enjoyed the mation, felt the necessity of coming together support of the 'Gerrit Jan Mulder Foundation', from time to time to exchange ideas about their which aims to promote post-doctoral training in work. The desire for such informal gatherings led the Medical Faculty of the Erasmus University to the foundation of the Inflammation Section of Rotterdam. We are particularly obliged to Dr M.
List of contents
The Inflammatory Reaction.- Past and present views on inflammation.- Some experimental models for the study of inflammation and anti-inflammatory drugs.- Histopathology of acute and chronic inflammation.- Vascular events in inflammation.- Cellular Aspects of Inflammation.- Cell kinetics during inflammation.- Leucocytes and chemotaxis.- Interaction between lymphocytes and macrophages.- Platelets and inflammation.- Humoral Mechanisms in Inflammation.- The mediator concept as it developed: Histamine and Bradykinin.- Prostaglandins and related compounds.- Lysosomal enzymes of phagocytic cells as humoral mediators of inflammation: modulation of their release by cyclic nucleotides.- Endogenous substances as modulators of inflammation.- Control of Inflammation.- Arthritis: a clinical model of inflammation.- Interaction between anti-inflammatory drugs and inflammatory mediators. A reference to products of arachidonic acid metabolism.- Cytotoxic agents in anti-inflammatory therapy.- Clinical evaluation of novel anti-rheumatic drugs.- Side effects of anti-inflammatory drugs: are they essential or can they be circumvented?.
