Drug Resistance in Cancer - Mechanisms and Models

Klappentext An accessible and sophisticated account of the biological mechanisms of drug resistance in cancer and their mathematical modelling. Zusammenfassung This book provides an accessible yet sophisticated account of the mechanisms responsible for drug resistance in cancer. In addition! the authors use clearly explained mathematical models to provide an insight into tumour development and the effectiveness and limitations of drug treatment. Inhaltsverzeichnis Preface; 1. The biological basis of cancer and the problem of drug resistance; 2. Tumour growth, stem cells and experimental chemotherapy; 3. Molecular aspects of drug resistance; 4. Quantitative descriptions of the origins of drug resistance; 5. Development and exploration of the random mutation model for drug resistance; 6. Extensions of the random mutation model for drug resistance; 7. Clinical predictions of the random mutation model; 8. Directed versus random mutation and the problem of intrinsic resistance; 9. Some final thoughts on the problem of drug resistance; Index.

Product details

• Authors: Andrew J. Coldman, Coldman Andrew J., J. H. Goldie, J.h. Coldman Goldie, James H. Goldie, James H. (University of British Columbia Goldie, Goldie James H.
• Publisher: Cambridge University Press ELT
• Languages: English
• Product format: Paperback / Softback
• Released: 11.06.2009
• EAN: 9780521111706
• ISBN: 978-0-521-11170-6
• No. of pages: 256
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; MEDICAL / Pharmacology, Oncology, Pharmacology, MEDICAL / Oncology / General