Signalling from Internalised Growth Factor Receptors

This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.

List of contents

List of Contents.- Receptor Tyrosine Kinase Signaling and Trafficking-Paradigms Revisited.- Met Receptor Dynamics and Signalling.- Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor.- Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction.- Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors IL-2R Endocytosis and Signalling.- Signaling Through Monoubiquitination.

Product details

• Assisted by: Inger Helena Madshus (Editor), Inge Helene Madshus (Editor), Inger Helene Madshus (Editor), Inger Helene Madshus (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 11.10.2010
• EAN: 9783642059124
• ISBN: 978-3-642-05912-4
• No. of pages: 190
• Illustrations: IX, 190 p. 31 illus., 4 illus. in color.
• Series: Current Topics in Microbiology and Immunology; Current Topics in Microbiology and Immunology
• Subjects: Natural sciences, medicine, IT, technology > Biology > Microbiology; C, Regulation, Biomedical and Life Sciences, Medical Microbiology, signal transduction, Intracellular trafficking