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The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.
List of contents
1. A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands
Hui-Ting Lee, Caroline Carr, Hollie Siebler, Lela Waters, Irine Khutsishvili, Fany Iseka, Brian Domack, Chris M. Olsen, and Luis Marky
2. Thermodynamics of Biological Processes
Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie Theriot and Rob Phillips
3. Protein stability in the presence of co-solutes
Luis Marcelo F. Holthauzen, Matthew Auton, Mikhail Sineva and Jorg Rosgen
4. Small Angle X-ray Scattering Studies of Peptide-Lipid Interactions using the Mouse Paneth Cell ?-Defensin Cryptdin-4
Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette and Gerard C. L. Wong
5. Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery
Rebecca Strawn, Thomas Stockner, Milan Melichercik, Lihua Jin, Wei-Feng Xue, Jannette Carey and Rüdiger Ettrich
6. Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes
C. Preston Moon1 and Karen G. Fleming
7. Non-B Conformations of CAG Repeats Using 2-aminopurine
Natalya N. Degtyareva and Jeffrey T. Petty
8. Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo
Jonathan P. Renn & Patricia L. Clark
9. Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native State: Application to the LID Domain of Adenylate Kinase from Escherichia coli
Travis P. Schrank, W. Austin Elam, Jing Li and Vincent J. Hilser
10. Fluorescence detected sedimentation in dilute and highly concentrated solutions
Jonathan S. Kingsbury and Thomas M. Laue
Summary
Presents methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. This title elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.
