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Filling a gap in the literature, leading expert editors and top international authors present the field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the application of different monooxygenases to applications in the pharmaceutical industry, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.
List of contents
1. INTRODUCTION AND HISTORY2. BIOOXIDATION FOR MEDICAL AND PHARMACEUTICAL RESEARCH2.1 Preparation of Drug Metabolites Using Fungal and Bacterial Strains2.2 Liver Monooxygenases2.3 Recombinant Human Liver Monooxygenases in Pharmacological Research2.4 Human Cytochrome P450 Monooxygenases - A General Model of Substrate Specificity and Regioselectivity2.5 Steroid Oxidation3. BIOOXIDATION FOR BIOCATALYSIS AND ORGANIC SYNTHESIS3.1 Selective Microbial Oxidations in Industry3.2 PQQ- and FAD-Dependant Oxidases3.3 Laccases and their Applications3.4 Dioxygenases and their Applications3.5 Heme Monooxygenases: A Superfamily, their Substates and their Applications3.6 Electroenzymologie with Monooxygenases: Challenges, Perspectives and Practical Considerations3.7 Baeyer-Villiger Monooyxgenases3.8 Heme Monooxygenases: The Reductase Issue3.9 A Modular Approach to Biotransformation Using Microbial Cytochromes4. PLANT MONOOXYGENASES AND THEIR APPLICATIONS5. COFACTOR REGENERATION6. BIOOXIDATION IN INDUSTRY
About the author
Rolf Schmid obtained his PhD in 1970. After post-doctoral studies in France and the USA, he joined the research laboratories of Henkel KGaA in Düsseldorf in 1972 where he became Director of the Biotechnology Laboratories. In 1987, he moved to the 'Gesellschaft für Biotechnologische Forschung' (GBF) in Braunschweig where he headed the Division of Enzyme Technology and Natural Products Research.In 1993, he accepted an invitation to build up the newly founded Institute for Technical Biochemistry at the University of Stuttgart. He is further in charge of the Department of Molecular Biotechnology at the Fraunhofer Institute for Membrane Science and Biotechnology in Stuttgart, and he is chairman of the IUPAC Commission of Biotechnology.
Summary
Filling a gap in the literature, leading expert editors and top international authors present the field of biooxidation from an academic and industrial point of view, taking many examples from modern pharmaceutical research. Topics range from the application of different monooxygenases to applications in the pharmaceutical industry, making this volume of high interest not only for those working in biotechnology but also for organic synthetic chemists, among others.
Report
"This book should be of value to those interested in developing such processes." ( Journal of Medicinal Chemistry , Volume 51, Number 10)
