Veterinary Neuropathology - Essentials of Theory and Practice

Informationen zum Autor Marc Vandevelde Dr.med.vet., DECVN is a professor of neurology in the Division of Neurological Sciences, Vetsuisse Faculty at the University of Bern, Switzerland. Robert J. Higgins BVSc, MS, PhD, DACVP is a professor of pathology in the Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, at the University of California Davis, Davis, California, USA. Anna Oevermann Dr. med.vet., DECVP is an associate professor of neuropathology in the Division of Neurological Sciences , Vetsuisse Faculty at the University of Bern, Switzerland. Klappentext Introducing the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition.It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species. Based on the authors' extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful.* An essential manual for daily diagnostic work* Richly illustrated with high quality colour gross, histological and MRI images* Includes a section on the function and use of MRI (by Johann Lang, DECVDI)* Accompanied by a website presenting MRI sequences for interpretation and correlation with neuropathological findings edited by Johann Lang (University of Bern, Switzerland) and Eric Wiesner (University of California, Davis, USA): www.wiley.com/go/vandevelde/veterinaryneuropathology Zusammenfassung A concise, well-illustrated book which introduces the theoretical and practical basics of veterinary neuropathology, based on the authors' extensive clinical and teaching experience. The book teaches neuropathology from scratch not only for pathologists and neurologists but also other interested groups - particularly imaging specialists. Inhaltsverzeichnis Preface ix Foreword x 1 General neuropathology 1 1.1 Principles of neuroanatomy for diagnostic neuropathologists 1 1.1.1 Anatomical orientation by using the ventricular system 1 1.1.2 Major anatomical regions of interest 2 1.1.3 Histological neuroanatomy 7 1.2 Neuropathological techniques 11 1.2.1 Necropsy techniques 11 1.2.2 Brain sectioning, macroscopic inspection and sampling for histology 12 1.3 Basic tissue reaction patterns 14 1.3.1 Reactions of neurons to injury 14 1.3.2 Oligodendrocytes 20 1.3.3 Astrocytes 20 1.3.4 Microglia/macrophages 22 1.3.5 CSF spaces 23 1.3.6 Blood vessels 23 1.3.7 Disturbance of water balance: edema 24 1.3.8 Artifacts, postmortem degeneration, pseudolesions and old age 26 1.4 Recognizing major lesion patterns 28 1.4.1 The major lesion patterns 28 1.4.2 Lesion distribution pattern 31 1.4.3 Classification of neurological diseases 31 1.4.4 General strategy 33 1.5 Neuropathology in the clinics: magnetic resonance imaging (MRI) 33 1.5.1 Basic MRI physics 33 1.5.2 Principles of i...

List of contents

Preface ix
 
Foreword x
 
1 General neuropathology 1
 
1.1 Principles of neuroanatomy for diagnostic neuropathologists 1
 
1.1.1 Anatomical orientation by using the ventricular system 1
 
1.1.2 Major anatomical regions of interest 2
 
1.1.3 Histological neuroanatomy 7
 
1.2 Neuropathological techniques 11
 
1.2.1 Necropsy techniques 11
 
1.2.2 Brain sectioning, macroscopic inspection and sampling for histology 12
 
1.3 Basic tissue reaction patterns 14
 
1.3.1 Reactions of neurons to injury 14
 
1.3.2 Oligodendrocytes 20
 
1.3.3 Astrocytes 20
 
1.3.4 Microglia/macrophages 22
 
1.3.5 CSF spaces 23
 
1.3.6 Blood vessels 23
 
1.3.7 Disturbance of water balance: edema 24
 
1.3.8 Artifacts, postmortem degeneration, pseudolesions and old age 26
 
1.4 Recognizing major lesion patterns 28
 
1.4.1 The major lesion patterns 28
 
1.4.2 Lesion distribution pattern 31
 
1.4.3 Classifi cation of neurological diseases 31
 
1.4.4 General strategy 33
 
1.5 Neuropathology in the clinics: magnetic resonance imaging (MRI) 33
 
1.5.1 Basic MRI physics 33
 
1.5.2 Principles of interpretation 34
 
Further reading 36
 
Neuropathology general 36
 
Neurology/functional neuroanatomy 36
 
Neuroanatomy 37
 
Techniques for PNS and muscle 37
 
Basic tissue reaction patterns 37
 
Edema 37
 
Artifacts, pseudolesions, old age 37
 
Magnetic resonance imaging 37
 
2 Vascular disorders 38
 
2.1 Pathophysiology of ischemia 38
 
2.2 General strategy for diagnosing vascular lesions 38
 
2.3 Common vascular lesions 39
 
2.3.1 Vascular lesions of the brain 39
 
2.3.2 Vascular lesions of the spinal cord 44
 
2.3.3 Ischemia in the peripheral nervous system and muscles 46
 
Further reading 46
 
Cerebral infarcts 46
 
Hemorrhage 46
 
Hypertensive encehalopathy 46
 
Fibrocartilagenous emboli 47
 
Aortic thrombosis 47
 
3 Inflammatory diseases 48
 
3.1 Pathophysiology of inflammation 48
 
3.1.1 Entry and effect of infectious agents in the nervous system 48
 
3.1.2 Immune reaction of the host against the infectious agent in the CNS 48
 
3.1.3 Morphological aspects of the immune response 49
 
3.2 General strategy for diagnosis of inflammatory lesions 50
 
3.2.1 Recognizing major inflammatory reaction patterns 51
 
3.2.2 Determining the distribution pattern of the lesions 52
 
3.2.3 Specifi c features 52
 
3.3 Common CNS infections 54
 
3.3.1 Neurotropic viral infections 54
 
3.3.2 Viral granulomatous inflammation 58
 
3.3.3 Viral vasculitis 60
 
3.3.4 Viral leukoencephalitis 61
 
3.3.5 Bacterial infections 63
 
3.3.6 Mycotic and algal infections 68
 
3.3.7 Protozoal infections 69
 
3.3.8 Helminth infections 70
 
3.4 Non-infectious and immune-mediated inflammatory lesions 72
 
3.4.1 Definition 72
 
3.4.2 Neurological diseases assumed to be immune-mediated 73
 
Further reading 79
 
General 79
 
Neurotropic viral infections 79
 
Viral granulomatous infections 79
 
Viral vasculitis 79
 
Demyelinating viral infections 79
 
Bacterial infections 79
 
Fungal infections 80
 
Protozoal infections 80
 
Helminth infections 80
 
Non-infectious and Immune-mediated inflammatory disorders 80
 
4 Trauma 81
 

Report

"In summary, this is an excellent, well-priced textbook that will be invaluable to practitioners and particularly residents in pathology and neurology training." (Veterinary Pathology, 1 January 2014)
 
"This book is not only written for specialists but it will help general practitioners understand better the various mechanisms of neurological diseases in many different species. The linked website presents RMI sequences and more neuropathological findings." (Vets Today, 1 June 2013)
 
"Add color gross, histological and MRI images and you have a key reference any veterinary collection must have." (Midwest Book Reviews, 1 May 2013)
 
"Thus, 'Veterinary Neuropathology' by Vandevelde, Higgins and Oevermann is an ideal aid for the visual approach to structural lesions of the nervous system. If you are a neurophilic veterinarian, don't leave this book out of your bookshelf unless it has been translocated already to your desk and is open in front of your eyes." (Veterinary Record, 6 April 2013)

Product details

• Authors: Rober Higgins, Robert Higgins, Robert (Department of Pathology Higgins, Anna Oevermann, M Vandevelde, Mar Vandevelde, Marc Vandevelde, Marc (Neurocenter Vandevelde, Marc (University of Bern Vandevelde, Marc Higgins Vandevelde, Vandevelde Marc
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 30.10.2012
• EAN: 9780470670569
• ISBN: 978-0-470-67056-9
• No. of pages: 224
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Veterinary medicine; Veterinärmedizin, veterinary medicine, Neuropathologie, Veterinärmedizin / Innere Medizin, Veterinary Internal Medicine, Veterinärmedizin / bildgebende Verfahren, Veterinary Imaging