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All of us have lurking in our DNA a most remarkable gene, which has a crucial job - it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures - the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.
List of contents
Preface
Chapter 1: Flesh of our Own Flesh
Chapter 2: The Enemy Within
Chapter 3: Discovery
Chapter 4: Unseeable Biology
Chapter 5: Cloning the Gene
Chapter 6: A Case of Mistaken Identity
Chapter 7: A New Angle on Cancer
Chapter 8: p53 Reveals its True Colours
Chapter 9: Master Switch
Chapter 10: 'Guardian of the Genome'
Chapter 11: Of Autumn Leaves and Cell Death
Chapter 12: Of Mice and Men
Chapter 13: The Guardian's Gatekeeper
Chapter 14: The Smoking Gun
Chapter 15: Following the Fingerprints
Chapter 16: Cancer in the Family
Chapter 17: The Tropeiro Connection?
Chapter 18: Jekyll and Hyde
Chapter 19: Cancer and Ageing: A Balancing Act
Chapter 20: The Treatment Revolution
Dramatis Personae
Glossary
Notes on Sources
Acknowledgements
Index
Report
More than any textbook, article, or lecture could, this book offers a sip of contagious enthusiasm and a conviction that scientists will eventually "crack the cancer code" Science 20150526
