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Informationen zum Autor KAROL GRELA is a Professor at the Institute of Organic Chemistry, Polish Academy of Sciences, and the Director of the Organometallic Synthesis Laboratory at the Biological and Chemical Research Centre of the Faculty of Chemistry, University of Warsaw, Poland. Having written over 100 peer-reviewed papers, he is on the editorial board of Chemistry-a European Journal and on the advisory board for the European Journal of Organic Chemistry and Organometallics . Klappentext A complete examination of modern olefin metathesis, one of the most widely used chemical reactions Garnering the 2005 Nobel Prize in chemistry for its discoverers, olefin metathesis has gained widespread use in research and industry for making products like medicines, polymers, and enhanced fuels. Olefin Metathesis offers a comprehensive analysis of the field, providing basic and necessary information for non-specialists while explaining the latest trends and advancements for experts. Acting as a guidebook, chapters include in-depth discussion on essential topics: Various types of metathesis reactions like CM, RCM, enyne metathesis, ROMP, and tandem processes, as well as their applications Tools of the trade, from the important classes of active metal complexes to optimal reaction conditions Tips to help chemists choose the right catalysts and determine substrate scope Select and representative procedures for each metathesis class Practical solutions and explanations for common reaction problems Included at the end of the book are tables with structures of commercial catalysts and recommendations for catalyst suppliers. With contributions from a multinational group of leading experts and practitioners in the field, this is an essential compendium for chemists at all levels. Zusammenfassung Olefin Metathesis is a complete examination of the theory and methods behind one of the most widely used chemical reactions in research and industry. It provides basic information for non-specialists! while explaining the latest trends and advancements in the field to experts. Inhaltsverzeichnis PREFACE ix CONTRIBUTORS xi PART I APPLICATIONS OF OLEFIN METATHESIS REACTIONS 1 Section I INTRODUCTION 3 1 Olefin Metathesis Reactions: From a Historical Account to Recent Trends 5 Didier Astruc Section II TYPES OF OLEFIN METATHESIS REACTIONS 37 2 Cross Metathesis 39 Karolina ¿ Zukowska and Karol Grela 3 Ring-Closing Metathesis 85 Bianca J. van Lierop, Justin A. M. Lummiss, and Deryn E. Fogg 4 Ene-Yne Metathesis 153 Steven T. Diver and Justin R. Griffiths 5 Domino and Other Olefin Metathesis Reaction Sequences 187 Bernd Schmidt and Stefan Krehl 6 Enantioselective Olefin Metathesis 233 Brice Stenne and Shawn K. Collins 7 Olefin Metathesis Polymerization 269 Astrid-Caroline Knall and Christian Slugovc Section III APPLICATIONS OF OLEFIN METATHESIS REACTIONS 285 8 Applications in the Synthesis of Natural and Biologically Active Molecules 287 Janine Cossy 9 Multifold Ring-Closing Olefin Metatheses in Syntheses of Organometallic Molecules with Unusual Connectivities 311 Tobias Fiedler and John A. Gladysz 10 Industrial Applications of Olefin Metathesis Polymerization 329 Christian Slugovc 11 Commercial Potential of Olefin Metathesis of Renewable Feedstocks 335 Andrew Nickel and Richard L. Pederson 12 Challenges and Opportunities for Scaling the Ring-Closing Metathesis Reaction in the Pharmaceutical Industry 349 Keith R. Fandrick, Jolaine Savoie, Nathan Yee, Jinhua J. Song, and Chris H. Senanayake PART II DEVELOPMENT OF THE TOOLS 367 Secti...
