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The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches.The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system.Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.
List of contents
PrefaceIntroductionChapter 1: Immune privilege of the brainChapter 2: Innate Immunity in the CNS - A Focus on the Myeloid CellChapter 3: Adaptive Immune Responses in the CNSChapter 4: Ageing and the immune response in the CNSChapter 5: Brain repair: The role of endogenous and transplanted neural stem cellsChapter 6: Neuroinflammation in Alzheimer's, Parkinson's and Huntington's DiseasesChapter 7: CNS InfectionsChapter 8: Neuroimmunology of Amyotrophic Lateral SclerosisChapter 9: Demyelinating Disorders of the CNSChapter 10: Other autoimmune disorders: Systemic Lupus Erythematosus, Primary Sjögren's syndrome, Gluten-related Neurological Dysfunction and Paraneoplastic Neurological SyndromesChapter 11: Inflammation in the pathogenesis of depressionChapter 12: Immune responses in the CNS in EpilepsyChapter 13: Inflammatory Mediators and Dysfunction of the Neurovascular Unit following Ischaemia ReperfusionChapter 14: Spinal cord injuryChapter 15: Immune Responses to Tumours in the CNSIndex
Summary
The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches.
The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system.
Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.
