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For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.
List of contents
Section A: Background.- 1. Local Regulation of Allograft Rejection.- 2. Pharmacokinetic Advantage of Regional Drug Delivery.- 3. Early Studies of Local Immunosuppression (1964-1984).- Section B: Pump-Based Local Infusion in Rat Allograft Models.- 4. Selective Immunosuppression by Local Treatment of the Allograft: Studies on Intrarenal Prednisolone and Intracardiac Budesonide Delivery in the Rat.- 5. Local Immunosuppression of Rat Cardiac, Liver, and Small Bowel Allografts.- 6. Inhibition of Cardiac Allograft Rejection by Continuous Local Infusion of 16,16 Di-Methyl PGE2.- 7. Intrarenal Administration of Anti T Cell-Monoclonal Antibody.- 8. Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allografts.- Section C: Pump-Based Local Infusion in Canine Allograft Models.- 9. Local Heparin, 6-Mercaptopurine, Prednisolone, and Mizoribine Delivery in a Canine Renal Allograft Model.- 10. Intraportal Cyclosporine A in Canine Liver Transplantation.- Section D: Other Drug Targeting Systems for Achieving Local Immunosuppression.- 11. Liposomal Cyclosporine A.- 12. Liposomal FK506 in a Canine Hepatic Allograft Model.- 13. Cyclosporine Aerosol in Lung Transplantation.- 14. Site-Specific Immunosuppression with Topical Agents.- 15. Local Immunosuppression in Corneal Transplantation.- 16. Controlled-Release Drug Matrices for Local Immunosuppression of Organ Transplants.- 17. Gene Transfer to the Transplanted Organ.- 18. Immunomodulation of Islet Allografts with Genetically Modified Muscle Cells.- 19. Sertoli Cells in Islet Transplantation: Testicular Immune Privilege.- Section E: Conclusion.
