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Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.
List of contents
Cytotoxic T Cell Effector and Memory Function in Viral Immunity.- Transgenic Mouse Models of Experimental Autoimmune Encephalomyelitis.- The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice.- Influence of T Lymphocytes and Major Histocompatibility Complex Class II Genes on Diabetes Susceptibility in the NOD Mouse.- Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis.- Role of HLA-B27 in Spondyloarthropathies.- The Influence of Cytokines on the Central Nervous System of Transgenic Mice.- Mx Transgenic Mice - Animal Models of Health.- Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis.- Transgenic Models of HTLV-I Mediated Disease and Latency.- Transgenic Models of Human Immunodeficiency Virus Type-1.- Transgenic Models in the Study of AIDS Dementia Complex.- Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice.- Transgenetics of Prion Diseases.- Poliovirus Biology and Pathogenesis.- Safety Requirements for Maintenance and Distribution of Transgenic Mice Susceptible to Human Viruses: The Example of Poliovirus-Susceptible Transgenic Mice.
