The Immunopathology of Lymphoreticular Neoplasms

Until recently, understanding of the lymphomas was limited and largely descriptive. Attention has been focused, for the most part, upon morphological issues and clinical matters. Although useful, this approach has many shortcomings. The true cytoidentity of primary neoplastic cells was not established by these methods, nor could their clonal nature be recognized. The more overt changes in immunological function, such as monoclonal gammopathies and immunodeficiencies, were appre ciated as important components of these diseases. However, subtle immunological perturbations were not recognized. Furthermore, associations were not established between the lymphoreticular neoplasms on the one hand and both primary and secondary immunological abnormalities on the other. There has been considerable recent progress in the fields of immunobiology, cytology, and immunochemistry. These new approaches have proved readily applicable to studies on the lymphomas. The term "lymphoma" has been applied to a heterogeneous group of neo plasms that involve lymphoid tissues. This term is not altogether satisfactory, since it implies that cells of primarily the lymphoid series are involved in the neoplastic process. Some neoplasms, heretofore classified as "lymphomas," now appear, from the results of penetrating analysis using newer methodology, to be malignan cies of the macrophage series, rather than of the lymphocytic series. These neo plasms include Hodgkin's disease and a minority of neoplasms previously referred to as "histiocytic" lymphomas. The majority of these "histiocytic" lymphomas are now known to be lymphoid malignancies involving the B-cell series.

List of contents

1 Development of Lymphoid Tissues.- 2 Regulation of the Immune Response.- 3 Aging and Involution of the Immunological Apparatus.- 4 Experimental Models of Lymphoid Malignancies.- 5 Epidemiology of Primary Neoplasms of Lymphoid Tissues in Animals.- 6 Epidemiology of Lymphoreticular Malignancies in Man.- 7 Immunodeficiency Diseases and Malignancy.- 8 Immunosuppression and Malignant Disease.- 9 The Pathology of Lymphoreticular Neoplasms.- 10 Cytoidentity of the Lymphoreticular Neoplasms.- 11 Ecotaxis, Ecotaxopathy, and Lymphoid Malignancy: Terms, Facts, and Predictions.- 12 Immunoglobulins in the Normal State and in Neoplasms of B Cells.- 13 Burkitt's Lymphoma and Infectious Mononucleosis.- 14 ?-Chain Disease: A Possible Model for the Pathogenesis of Human Lymphomas.- 15 Lymphoreticular Disorders of the Gastrointestinal Tract: Roentgenographic Features.- 16 Proliferative Disorders of the T-Cell Series.- 17 Lymphoreticular Malignancies in Childhood.- 18 Immunodeficiency States Associated with Acute Leukemias, Multiple Myeloma, and Waldenström's Macroglobulinemia.- 19 Immunodeficiencies Associated with Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphomas.- 20 Immunological Changes with Hodgkin's Disease.- 21 Non-Hodgkin's Lymphoma in Children: Historical Review, Patterns of Disease, and Future Trends.- 22 Biology, Clinical Patterns, and Treatment of Multiple Myeloma and Related Plasma-Cell Dyscrasias.- 23 Treatment of Primary Neoplasms of Lymphoid Tissues.

Summary

Until recently, understanding of the lymphomas was limited and largely descriptive. Attention has been focused, for the most part, upon morphological issues and clinical matters. Although useful, this approach has many shortcomings. The true cytoidentity of primary neoplastic cells was not established by these methods, nor could their clonal nature be recognized. The more overt changes in immunological function, such as monoclonal gammopathies and immunodeficiencies, were appre­ ciated as important components of these diseases. However, subtle immunological perturbations were not recognized. Furthermore, associations were not established between the lymphoreticular neoplasms on the one hand and both primary and secondary immunological abnormalities on the other. There has been considerable recent progress in the fields of immunobiology, cytology, and immunochemistry. These new approaches have proved readily applicable to studies on the lymphomas. The term "lymphoma" has been applied to a heterogeneous group of neo­ plasms that involve lymphoid tissues. This term is not altogether satisfactory, since it implies that cells of primarily the lymphoid series are involved in the neoplastic process. Some neoplasms, heretofore classified as "lymphomas," now appear, from the results of penetrating analysis using newer methodology, to be malignan­ cies of the macrophage series, rather than of the lymphocytic series. These neo­ plasms include Hodgkin's disease and a minority of neoplasms previously referred to as "histiocytic" lymphomas. The majority of these "histiocytic" lymphomas are now known to be lymphoid malignancies involving the B-cell series.

Product details

• Assisted by: Robert A. Good (Editor), Twomey (Editor), J Twomey (Editor), J. Twomey (Editor), J. J. Twomey (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 18.10.2013
• EAN: 9781461340171
• ISBN: 978-1-4613-4017-1
• No. of pages: 764
• Illustrations: XX, 764 p.
• Series: Comprehensive Immunology; Comprehensive Immunology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine