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The pUrpOSE! of this conference was not to define the two areas that are being bound, which might be a well nigh impossible proposition. Rather, its focus was to concentrate on the mechanistic similarities between promotion and progression. Are the areas involved within the boundaries a continuum? Are these two simultaneous processes? Or are some of the affected cells in the stage of promotion when at the same time others have undergone irreversi ble changes tha. t position them in the stage of progression? Or are these two stages the same thing, but called by different names? To explore such concepts we assembled investigators with various back grounds and asked them to specifically address these and other questions about "The Boundaries", within the context of the session to which they con tributed. The conference lasted two and a half days, from Wednesday to Friday. There were at least four speakers per session with morning and after noon sessions each day, except on Friday when the meeting ended at noon. The first day, each speaker had 25 minutes to present a position, followed by five minutes of discussion. At the end of the session there were 40 or 50 minutes of exchange on all the issues examined. For the remaining days, there were 25 minutes of presentation and 15 minutes of discussion.
List of contents
Introduction: Is there a Boundary Between Promotion and Progression.- Session I: The Boundaries between Promotion and Progression in Different Tissues.- Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rat.- Critical Events in Skin Tumor Promotion and Progression.- Malignant Conversion, the First Stage in Progression, is distinct from Phorbol Ester Promotion in Mouse Skin.- Boundaries in Mammary Carcinogenesis.- Discussion of Session.- Session II: Development and Boundaries between Promotion and Progression.- Progression in Teratocarcinomas.- Developmental Potential of Murine Pluripotent Stem Cells.- Summary by Moderator:.- Colloquium: Transgenic Mice and the Boundaries between Promotion and Progression.- Tumor Progression in Transgenic Mice Containing the Bovine Papillomavirus Genome.- SV40 T Antigen Transgenic Mice: Cytotoxic T Lymphocytes as a Selective Force in Tumor Progression*.- Session III: Oncogenes, Suppressor Genes and the Boundaries between Promotion and Progression.- Differential Gene Expression During Tumor Promotion and Progression in the Mouse Skin Model.- Oncogenes and Breast Cancer Progression.- Gene Amplification During Stages of Carcinogenesis.- Recessive Mutations in Cancer Predisposition and Progression.- Role of Tumor Suppressor Genes in a Multistep Model of Carcinogenesis.- Cancer Genes by Non-Homologous Recombination.- Discussion of Session.- Session IV: Genetic Instability and the Boundaries between Promotion and Progression.- Genetic Instability and Tumor Development.- Unknown Primary Tumors: An Example of Accelerated (Type 2) Tumor Progression.- Discussion by Moderator.- Colloquium: At Which Point in Time Does Genetic Instability Occur in the Natural History of Cancer?.- Tumor Heterogeneity and Intrinsically Chemoresistant Subpopulations in Freshly Resected Human Malignant Gliomas.- Genetic Instability Occurs Sooner Than Expected: Promotion, Progression and Clonality During Hepatocarcinogenesis in the Rat.- Clonal Analysis of Neoplastic Transformation in Cultured Diploid Rat Liver Epithelial Cells.- Epigenetic Features of Spontaneous Transformation in the NIH 3T3 Line of Mouse Cells.- Session V: The Boundaries between Promotion and Progression in Humans.- The Human Melanocyte System as a Model for Studies on Tumor Progression.- Early and Late Events in the Development of Human Breast Cancer.- Malignant Progression in Harvey Ras Transformed Normal Human Bronchial Epithelial Cells.- Identification and Characterization of Differentially Expressed Genes in Tumor Metastasis: The nm23 Gene.
Summary
Based on a conference held in Cleveland, Ohio, September 28--30, 1988
