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Over the past 5 years, clinical immunology, as a whole, has advanced more rapidly than over the past 20 years. Many of these advances have been que to monoclonal antibody technology with its ability to identify antigens on tumour cells with a precision never before available. Monoclonal antibodies have the ability to identify subsets of human T-Iymphocytes and aid in diagnosis of both immunodeficiency disorders such as AIDS, or autoimmune diseases, and they can be adapted as drug targeting agents. Additionally, however, major advances have been made in identifying immunomodulating agents, and the last year has seen two such agents, IL-2 and OKT3, made available commercially for such intervention. Furthermore, another immuno modulating technique, bone marrow transplantation, ha~ now been established as a curative modality in leukaemia treatment. A central issue in tumour immunology is whether human tumours express antigens which can be termed tumour-specific. This has important implications for both tumour immunity as well as drug targeting. This issue is considered in detail by R. A. Robins in the introductory chapter in which the expression of antigens in human tumours is compared with that in experimentally induced animal tumours. This controversial issue is also considered in later chapters by Bast in breast carcinoma, Riimke and de Vries in melanoma, V{mky in lung cancer, Armitage in colorectal cancer, and Paulie and Perlmann in bladder carcinoma.
List of contents
1 Basic tumour immunology.- 2 Immunoscintigraphy: tumour detection with radiolabelled antitumour monoclonal antibodies.- 3 Monoclonal antibody targeting of cytotoxic agents for cancer therapy.- 4 Bone marrow transplantation.- 5 Immunomodulating agents.- 6 Immunology in bowel cancer.- 7 Recognition of autologous tumour cells by blood lymphocytes in patients with lung cancer.- 8 Melanoma.- 9 Immunological features of human bladder cancer.- 10 Immunobiology of human breast cancer.- 11 Acquired immune deficiency syndrome.
Report
`This book provides an overview of many of the most recent developments in this field, with the benefit of plentiful recent references. It should be of interest both to oncologists and clinical researchers.'
Oncology Information Service.
