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The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 22 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invaluable reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
List of contents
1 Translation of Animal Virus mRNAs in Vitro.- 1. Introduction.- 2. Preparation and Comparative Properties of in Vitro Protein-Synthesizing Systems.- 3. Translation of DNA Virus mRNAs.- 4. Translation of RNA Virus mRNAs.- 5. Factors Affecting Efficiency of Translation of Viral mRNAs in Vitro.- 6. Conclusions.- 7. References.- 2 Defective Interfering Animal Viruses.- 1. Introduction.- 2. General Properties.- 3. Viral Systems Containing DI Particles.- 4. DI Particles and Viral Disease.- 5. References.- 3 Virion Polymerases.- 1. Introduction.- 2. Proof That Polymerases Are Virion Components.- 3. Product Analyses of Virion Polymerase Reactions.- 4. Conclusions.- 5. References.- 4 Animal Virus-Host Genome Interactions.- 1. Introduction.- 2. Methods Used to Demonstrate Integration of Viral Genomes.- 3. Bacteriophage Models.- 4. Adenoviruses.- 5. Simian Virus 40 (SV40).- 6. Polyoma Virus.- 7. The Adeno-SV40 Hybrid Viruses.- 8. Herpesvirus.- 9. Integration of the Genome of RNA Tumor Viruses.- 10. Endogenous Viral DNA.- 11. Outlook.- 12. References.- 5 Cell Transformation by RNA Tumor Viruses.- 1. Introduction.- 2. Transforming Agents.- 3. Events in Transformation.- 4. Genes for Transformation.- 5. Mutants of Transforming Virus.- 6. Alteration of Cells by Transformation.- 7. Concluding Remarks.- 8. References.
