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This volume is based on the proceedings of a NATOjFEBSjGulbenkian Foundation sponsored Summer School held in September 1984 in Sintra Estoril, Portugal. Given the accelerated growth of knowledge in the field of cell transformation, it seemed timely to hold a summer school to discuss current developments in this area of biology as well as to evaluate emerging technology. The first article in this volume gives an evaluation of the various cellular systems to study neoplasia. Their properties as well as advantages and disadvantages are dis cussed. The second section deals with the role of oncogenes in cell transformation. Particular emphasis is given to the question of whether activated proto-one genes are cancer genes and to the func tions of oncogene products. The third part is dedicated to viruses and includes articles on papova viruses, Epstein-Barr virus, adeno virus, parvo viruses and HTLV. The fourth part deals with gene ex pression in normal and transformed cells while the concluding sec tion considers various aspects of gene regulation in eukaryotic cell s. vi PREFACE We wish to express our appreciation to Dr. Maria C. Lechner who provided valuable advice and help concerning the organization of this meeting. We are also indebted to Ms. Lisbeth Heilesen and Ms. Anne Mette Lygaard for typing the manuscripts and for their out standing administration of the meeting. J. E. Cel is February 1985 A. Graessmann CONTENTS NEOPLASTIC TRANSFORMATION SYSTEMS 1. Neoplastic Transformation Systems - Their Use In Stu- ing Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
List of contents
Neoplastic Transformation Systems.- 1. Neoplastic Transformation Systems - Their Use In Studying Carcinogenesis.- Oncogenes.- 2. Are Activated Proto-onc Genes Cancer Genes?.- 3. Immunoglobulin Genes, Oncogenes, and Human B-Cell Tumors.- 4. The Functions of Oncogene Products.- 5. Identification and Localization of Phosphoproteins in v-onc Transformed Fibroblasts by Means of Phosphotyrosine Antibodies.- Viral Transformation.- 6. The Transformation Capacity of Early SV40 DNA Fragments.- 7. The Transforming Genes of Polyoma Virus.- 8. Papova Viruses and Cancer Genes.- 9. Epstein-Barr Virus and Immortalisation of Epithelial Cells.- 10. Functional Domains of Purified Adenovirus Type C E1A Proteins.- 11. Parvoviruses and Cancer.- 12. HTLV in Adult T Cell Leukemia and Acquired Immune Deficiency Syndrome.- Gene Expression in Normal and Transformed Cells.- 13. Construction of Protein Databases for Comparison of Normal and Transformed Cells.- 14. Cyclin (PCNA) is a Component of the Pathway(s) Leading and Cell Division: A Role in DNA to DNA Replication Replication?.- Regulation of Gene Expression.- 15. Regulation of Gene Expression in Developmental and Oncogenic Processes: The Albumin Alpha-Fetoprotein Locus in Mammals.- 16. Transcription Control in Eucaryotes-Enhancers and Promoters.- 17. Controls of Gene Expression in Chemical Carcinogenesis: Role of Cytochrome P450 Mediated Mono-Oxygenases.- Contributors.
