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This volume comprises a series of original articles, updates and reviews on relevant topics in hepatology which were presented at a meeting in Freiburg im Breisgau to honour the 60th anniversary of Dr. Herbert Falk. Since 1967, Dr. Falk and the Falk Foundation have generously sponsored more than 40 congresses and symposia on liver diseases, held mostly in Freiburg, The Black Forest or in Basel, which have become milestones in the ex change of scientific information in hepatology (see 'To Herbert Falk on his Sixtieth Birthday' in this volume). Many of these congresses and symposia have been published in the 'Falk Symposia' series by MTP Press. We asked hepatologists who took part in former Falk liver meetings to contribute to a one day symposium to celebrate Dr. Falk's anniversary. We were greatly gladdened by the spontaneous and unrestrained acceptance that we received from all sides. We wish to express our deep appreciation to all the speakers and moderators who travelled, at their own expense, from all parts of the world to Freiburg and who with their presentations, made the meeting a stimulating and refreshing event. The editors' thanks are also addressed to Mr. D. G. T. Bloomer and Mr. P. M. Lister from MTP Press for their valuable cooperation in preparing this volume for publication. This book testifies to the worldwide appreciation and gratitude held for Dr. Falk by the community of hepatologists. The Editors ix List of Contributors P. BACK K. F. A.
List of contents
Section 1.- 1 Bile acid research - the past 60 years.- 2 Bile acids in therapy - pre-1924, circa 1924 and in 1984.- 3 Progress in understanding the mechanisms of organic anion uptake by the liver.- 4 Biochemical pathways of transforming cholesterol.- 5 Bile acid metabolism in hepatobiliary diseases.- 6 Effect of female sex hormones on bile acids.- 7 The gallbladder after endoscopic papillotomy.- 8 Primary biliary cirrhosis: the present position.- Section 2.- 9 Synthetic hepatology.- 10 Studies on the molecular basis of polymorphic drug oxidation (debrisoquine/sparteine-type) in man.- 11 The role of tumour-promoting chemical in hepatocarcinogenesis.- 12 Recent trends in studies of the pathogenesis of hepatic encephalopathy.- 13 Urea synthesis and its enzymatic regulation.- 14 Leukotrienes and liver injury.- 15 Heterogeneous turnover of plasma membrane glycoproteins in the liver.- 16 The structure of connexons in the open and closed state as revealed by rotary shadowed freeze-fracture replicas of rat hepatocyte gap junctions.- 17 Insulin and liver disease: effect of proinsulin on hepatic carbohydrate metabolism.- Section 3.- 18 Wilson's disease.- 19 Studies on the development of Mallory bodies.- 20 Are constitutional factors and/or HLA phenotypes in males predisposing factors for alcoholic cirrhosis?.- 21 New aspects of piecemeal necrosis.- 22 The morphology of hepatitis A in man.- 23 Epstein-Barr virus in chronic hepatitis.
