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Seventeen cutting-edge chapters review both basic research and clinical applications of chromosomal markers of cancer. The new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The chapters-all written by leading authorities-skillfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated. A seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.
List of contents
Ch. 1. An Introduction to Cancer Markers and Cytogenetics,.- I. Perspectives: Relation of Other Genetic Measures to Cytogenetics.- Ch. 2. Assessment of Genetic Changes in Human Cancers Using Flow and Image Cytometry,.- Ch. 3. In Situ Hybridization and Comparative Genomic Hybridization,.- Ch. 4. Nucleic Acid Amplification Methods for Identifying Cytogenetic Abnormalities,.- II. Organ and Site-Specific Tumors.- Ch. 5. Direct Demonstration of Lineage Specificity in Hematologic Neoplasms,.- Ch. 6. Breast Tumor Cytogenetic Markers,.- Ch. 7. Karyotypic Characteristics of Colorectal Cancer,.- Ch. 8. Renal and Bladder Cancers,.- Ch. 9. Cytogenetic Markers in Selected Gynecological Malignancies,.- Ch. 10. Prostate Cancer,.- Ch. 11. Chromosomes in Lung Cancer,.- Ch. 12. Cytogenetic Biomarkers in Skin Cancer,.- Ch. 13. Brain Tumors,.- Ch. 14. Cytogenetic Abnormalities Associated with Endocrine Neoplasia,.- Ch. 15. Pancreatic Exocrine Tumors,.- Ch. 16. Soft Tissue Sarcomas,.- Ch. 17. Special Techniques in Cytogenetics,.
Report
". . .well written and well illustrated. . .contains a wealth of information. . .recommend[ed] to all pathologists who have an interest in the genetic mechanisms involved in cancer and to all pathologists who direct a cytogenetics or molecular genetics laboratory."-American Journal of Clinical Pathology
