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Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system in health and disease. The papers presented describe fundamental mechanisms underlying changes in the cellular machinery during the development of cardiac hypertrophy and heart failure.
Audience: Students, scientists, clinical and experimental cardiologists who seek to understand and manage the perplexing problems of hypertrophy and heart failure.
List of contents
A. Genetic and Molecular Events.- 1. Molecular analysis of genotype/phenotype correlations of hypertrophic cardiomyopathy.- 2. Molecular genetics: New mutations that cause familial hypertrophic cardiomyopathy.- 3. Genetically determined cardiomyopathies in neuromuscular disease.- 4. Mitochondrial DNA mutations and heart failure.- 5. Mutations of myocardial mitochondrial DNA in diabetic patients.- 6. Differential screening and megasequencing of human heart cDNA library: A search for genes associated with heart failure.- 7. Intracellular signaling and genetic reprogramming during development of hypertrophy in cultured cardiomyocytes.- 8. Phenotypic changes in experimental cardiac hypertrophy and failure in relation to changes in heart rate variability.- 9. Relationship between myocardial function and expression of calcium cycling proteins in nonfailing and failing human myocardium.- 10. Cardiac remodeling by alterations in phospholamban protein levels.- 11. Regulation of sarcoplasmic reticulum gene expression during cardiac hypertrophy and heart failure.- 12. Hormonal regulation of cardiac sarcoplasmic reticulum Ca2+-ATPase expression.- B. Cellular and Biochemical Mechanisms.- 13. Growth of the neonatal pig heart.- 14. Regulation of cardiac myocyte differentiation, hyperplasia, and hypertrophy during normal and stressed fetal and neonatal growth.- 15. Rat heterotopic cardiac isograft model: What atrophy teaches us about hypertrophy.- 16. Myocardial cell abnormalities in heart failure: Experience from studies on single myocytes.- 17. Depression of sarcolemmal phospholipase C activity in congestive heart failure.- 18 Does decreased energy supply contribute to heart failure? The role of the creatine kinase system.- 19 Molecular basis for depressed contractile performance inhuman heart failure.- 20 Cellular adaptations in hypertrophy and heart failure.- 21 Progressive ventricular dilatation in heart failure: The role of myocardial collagenase.- 22 Interaction between cardiac myocytes and the extracellular matrix in failing human myocardium.- 23 Role of transforming growth factor beta1 in the remodeling of collagen matrix in the heart.- 24 Cytokines modulate the expression of specific proteins of the contractile apparatus in rat myocytes.- C. Signal Transduction Abnormalities.- 25 Rethinking ras: p21 ras proteins and cardiac signal transduction.- 26 Regulation of ?MHC gene expression by cAMP.- 27 Cardiac hypertrophy and the renin-angiotensin system.- 28 Stimulation of ?-adrenoceptor subtypes causes different effects in cardiac cells.- 29 Significance of adrenergic stimuli for cardiac remodeling under chronic overload: Relative importance of myocardial factors versus ventricular geometry in cardiac failure.- 30 Sympathetic neuroeffector mechanisms in the failing and hypertrophied myocardium.- 31. Status of post adrenergic receptor mechanisms in cardiac hypertrophy and heart failure.- 32. Role of protein kinase C in the development of non-insulin-dependent diabetic cardiomyopathy.- 33. The alteration of signal transduction system in heart failure: renin-angiotensin system in diseased human heart.- 34. Neuroendocrine mechanisms in the pathogenesis of heart failure.- 35. Neurohormonal responses in congestive heart failure: effect of ACE inhibitors in randomized controlled clinical trials.
