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La pathologie vasculaire a ete tres marquee par les progres biologiques de ces vingt demieres annees. Le systeme arteriel est main tenant considere comme un organe a part entiere. Modelee au cours de l'organogenese par les facteurs hemodynamiques, Ie paroi arterielle maintient une structure hautement organisee et des proprietes mecaniques qui dependent directement des conditions de pression et de debit. La monocouche endotheliale developpe 2 une surface de plusieurs centaines de m a l'interface sang-tissu; elle est a la fois un organe endocrine complexe synthetisant de nombreuses proteines qui participent a l'hemostase, une surface thromboresistante et hemocompatible, une barriere de permeabilite contr6lant les echanges sang-tissus. Les cellules musculaires lisses constituent un tissu multifonctionnel, contractile, assurant la synthese des composants structuraux responsables des proprietes mecaniques de la paroi arterielle, la transmission de la force contractile, et une etonnante activite reparatrice en reponse aux agressions. Tout ceci est soumis a un ensemble complexe de communications cellulaires qui font de l'endothelium un veritable systeme recepteur pour la paroi vasculaire. Parallelement, ou a la suite de ces progres, l'angeiologie s'est progressivement affirmee comme une specialite clinique. Debordant Ie cadre de la chirurgie vasculaire, elle integre les concepts physiopathologiques au diagnostic et au traitement des maladies arterielles. De cet effort d'integration est ne cet ouvrage, cherchant a concilier les connaissances fondamentales es plus recentes et la demarche clinique.
List of contents
I Cellular and Molecular Biology of the Normal Arterial Wall.- 1 Endothelial and Smooth-Muscle Cells.- 2 Extracellular Matrix of the Arterial Vessel Wall.- 3 Organogenesis of the Arterial Wall.- 4 Age-Related Morphological Changes of the Arterial Wall.- 5 Effects of "Ageing" on Arterial Cells In Vitro.- 6 Structural Modifications of the Arterial Wall in Hypertension.- 7 Adrenergic and Non-adrenergic Neural Control of the Arterial Wall.- 8 The Arterial Wall and the Haemostatic Process.- 9 The Vascular Wall and Hormonal Control of Vasomotor Function.- II Pathophysiology of Experimental and Human Atherosclerosis.- 10 The Lesions of Atherosclerosis.- 11 Atherosclerosis: Cellular Aspects.- 12 Extracellular Matrix Changes in Atherosclerosis.- 13 Lipid Accumulation in the Vessel Wall.- 14 Role of Platelets in Atherosclerosis and its Complications.- 15 Mechanical Factors in the Pathogenesis, Localization and Evolution of Atherosclerotic Plaques.- 16 Progression, Topographical Aspects and Regression of Atherosclerosis.- III Management of Patients with Atherosclerosis.- 17 A Pharmacological Approach to Degenerative Alterations of Arterial Walls.- 18 The Arterial Wall: Relationships Between Haemodynamic and Structural Aspects in Man.- 19 The Epidemiology of Atherosclerosis.- 20 Risk Factors for Atherosclerosis: A Clinician's Pragmatic Appraisal.- 21 Diagnostic Principles and Therapeutic Management of Patients with Atherosclerosis.- IV The Arterial Wall in Diabetes.- 22 Clinical and Physiopathological Features in Diabetic Vascular Disease.- 23 Diabetic Retinopathy.- 24 Diabetic Nephropathy.- 25 Vascular Connective Matrices and Haemostasis in Diabetic Angiopathy.- V Inflammatory Diseases of the Arterial Wall.- 26 Immunological Processes in the Vascular Wall.- 27 The VasculitisSyndromes in Small- and Medium-Sized Vessels.- 28 The Vasculitis Syndromes in Aorta and Large Arteries.- VI Arteriopathies of Diverse Origin.- 29 Fibromuscular Arterial Dysplasias Pathological Aspects and Current Concepts.- 30 Cardiovascular Alterations in Inherited Connective Tissue Disorders.- 31 Aneurysms and Arterial Dissections.- 32 Traumatic Arterial Disease.- 33 Perioperative Arterial Changes.- VII Pathology of the Pulmonary Arteries.- 34 Pulmonary Vasculitides.- 35 Pulmonary Hypertension.- VIII Angiodysplasias, Tumours and Tumour-like Lesions of the Blood Vessels.- 36 Arteriovenous Malformations and Arterial Dysplasias.- 37 Tumours and Tumour-like Lesions.- 38 Diagnostic and Therapeutic Principles in Angiodysplasia.
