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One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.
This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Series Editor comments:
"The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
List of contents
Receptors.- Growth, Survival and Migration: The Trk to Cancer.- The Role of Growth Factor Signaling in Malignancy.- TGF-? Signaling Alterations in Cancer.- Notch in Malignancy.- Intracellular Pathways.- cAMP Signaling in Cancer Genesis and Treatment.- PI3K/PTEN/Akt Pathway.- Wnt Signaling in Human Cancer.- Ras Signaling, Deregulation of Gene Expression and Oncogenesis.- Role of the RB Tumor Suppressor in Cancer.- Transcription Factors.- The Rel/NF-?B/I?B Signal Transduction Pathway and Cancer.- STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies.- Steroid Hormone Receptor Signaling in Cancer.- Cell Death Pathways.- Cell Death Signaling in Malignancy.- Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies.
Summary
One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.
This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Series Editor comments:
"The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Additional text
"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research."
(Cancer Forum, 27:3)
Report
"While the chapters in this book are necessarily brief, all are extensively referenced and msot authors have included historical as well as more recent references. Thus this book is an excellent summary of important signalling pathways in cancer that will be useful for students and researchers. It will serve as a resource for general and specialised knowledge regarding these pathways as well as a platform for more detailed research."
(Cancer Forum, 27:3)
