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Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.
List of contents
1 Retrovirus Vectors and Regulatable Promoters.- 2 Characteristics of Adenovirus Vectors.- 3 HSV Recombinant Vectors: General Characteristics and Potential for Use in the Central Nervous System.- 4 HSV-1 Amplicon.- 5 AAV Vectors: General Characteristics and Potentialfor Use in the Central Nervous System.- 6 EBV Vectors: General Characteristics and Potential for Gene Therapy in the Central Nervous System.- 7 Lentiviral Vectors for Gene Delivery in the Central Nervous System.- 8 Promoters for Expression of Gene Products Within Neurons and Glia.- 9 Immune Response to Viral Vectors.- 10 Current Treatment Modalities for Brain Tumor: Surgery, Radiation, and Chemotherapy.- 11 Experimental and Clinical Gene Therapies for Brain Tumors.- 12 Tumor Suppressor Gene Therapy for Brain Tumors.- 13 Cytokine-Based Gene Therapy for Brain Tumors.- 14 Delivery of Therapeutic Genes to Brain and Intracerebral Tumors.- 15 Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology.- 16 Gene Transfer for Adult CNS Regeneration and Aging.- 17 Gene Therapy for Parkinson's Disease.- 18 Gene Therapy for Ischemic Stroke.- 19 Gene Therapy for the Lysomal Storage Diseases.- 20 Gene Therapy for Pain.- 21 Gene Therapy of Huntington's Disease.
Report
"a very interesting book. . .all 'gene therapy laboratories' and 'neuo-gene therapy laboratories' will be able to derive much intellectual nourishment and stimulation, practical tips, and predictions about the future from this truly challenging volume."-Human Genetics
