Silk Biomaterials for Tissue Engineering and Regenerative Medicine

Informationen zum Autor Subhas C. Kundu, PhD, is a Research Coordinator and former European Research Area Chair and Professor at the 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of the University of Minho, Portugal. His research interests include silk biomaterial matrices for biomedical applications, including 3D in vitro cancer models for investigating tumour growth and progression. In addition, he is using natural-based biomaterials for 3D cancer modelling and drug screening. Klappentext Silk has been used for centuries in medicine as sutures. The unique mechanical and chemical properties of this material and the ability to genetically tailor the protein has meant that this material is now being used increasingly for biomaterials and tissue engineering applications. This book discusses the properties and applications of silk for medical purposes. The first set of chapters discuss the fundamentals and properties of silk for biomedical applications. A second group of chapters look at a wide range of medical applications including tissue engineering and regenerative medicine, drug delivery and pharmaceutical applications. Zusammenfassung The unique mechanical and chemical properties of this material and the ability to genetically tailor the protein has meant that this material is now being used increasingly for biomaterials and tissue engineering applications. This book discusses the properties and applications of silk for medical purposes. Inhaltsverzeichnis Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Part I: Fundamentals, processing and types of silk biomaterials Chapter 1: Introduction to silk biomaterials Abstract: 1.1 Introduction 1.2 General information about silkworms 1.3 Silk proteins 1.4 Genetics of silkworms 1.5 Diseases of silkworms 1.6 Applications of silks 1.7 Application of silk protein fibroins 1.8 Application of silk protein sericins 1.9 Conclusion 1.10 Acknowledgments Chapter 2: Applications of silk biomaterials in tissue engineering and regenerative medicine Abstract: 2.1 Introduction 2.2 Silk scaffolds in tissue engineering and regenerative medicine 2.3 Hard tissue engineering 2.4 Soft tissue engineering 2.5 Tissue engineering for application in specific organs 2.6 Conclusion and future trends 2.7 Acknowledgments Chapter 3: Processing of Bombyx mori silk for biomedical applications Abstract: 3.1 Introduction 3.2 Modulation of silk biomaterial properties 3.3 Silk fibroin materials and their use in biomedical applications 3.4 Conclusion and future trends Chapter 4: Silk nanostructures based on natural and engineered self-assembly Abstract: 4.1 Introduction 4.2 Mechanisms of self-assembly in natural and engineered systems 4.3 Assembly of natural and recombinant silk proteins 4.4 Engineering the self-assembly of silk 4.5 Silk nano-architectures and their applications 4.6 Self-assembly in conjugation with other (bio)materials 4.7 Conjugation with natural and synthetic materials 4.8 Conclusion and future trends Chapter 5: Electrospun silk sericin nanofibers for biomedical applications Abstract: 5.1 Introduction 5.2 Application of silk sericin in the biomedical field 5.3 Electrospinning 5.4 Silk sericin nanofibers from electrospinning 5.5 Molecular structure and physical properties 5.6 Silk sericin/silk fibroin blend nanofibers by electrospinning 5.7 Conclusion and future trends Chapter 6: Silk fibroin microfiber and nanofiber scaffolds for tissue engineering and regeneration Abstract: 6.1 Introduction 6.2 Silk fibroin (SF) microfibers for skin and connective tissue regeneration 6.3 Formic acid (FA)-cross-linked 3-D SF microfiber-based nonwovens 6.4 SF microfiber-based carded-needled 3-D nonwovens 6.5 Nanofibers from electrospinning and tissue engineering 6.6 Electrospun SF tubes for small calibre blood vessel regeneration Chapter 7: Silk powder for regenerative medicine Abstrac...

List of contents

• Contributor contact details
• Woodhead Publishing Series in Biomaterials
• Foreword
• Part I: Fundamentals, processing and types of silk biomaterials
  • Chapter 1: Introduction to silk biomaterials
    • Abstract:
    • 1.1 Introduction
    • 1.2 General information about silkworms
    • 1.3 Silk proteins
    • 1.4 Genetics of silkworms
    • 1.5 Diseases of silkworms
    • 1.6 Applications of silks
    • 1.7 Application of silk protein fibroins
    • 1.8 Application of silk protein sericins
    • 1.9 Conclusion
    • 1.10 Acknowledgments
  • Chapter 2: Applications of silk biomaterials in tissue engineering and regenerative medicine
    • Abstract:
    • 2.1 Introduction
    • 2.2 Silk scaffolds in tissue engineering and regenerative medicine
    • 2.3 Hard tissue engineering
    • 2.4 Soft tissue engineering
    • 2.5 Tissue engineering for application in specific organs
    • 2.6 Conclusion and future trends
    • 2.7 Acknowledgments
  • Chapter 3: Processing of Bombyx mori silk for biomedical applications
    • Abstract:
    • 3.1 Introduction
    • 3.2 Modulation of silk biomaterial properties
    • 3.3 Silk fibroin materials and their use in biomedical applications
    • 3.4 Conclusion and future trends
  • Chapter 4: Silk nanostructures based on natural and engineered self-assembly
    • Abstract:
    • 4.1 Introduction
    • 4.2 Mechanisms of self-assembly in natural and engineered systems
    • 4.3 Assembly of natural and recombinant silk proteins
    • 4.4 Engineering the self-assembly of silk
    • 4.5 Silk nano-architectures and their applications
    • 4.6 Self-assembly in conjugation with other (bio)materials
    • 4.7 Conjugation with natural and synthetic materials
    • 4.8 Conclusion and future trends
  • Chapter 5: Electrospun silk sericin nanofibers for biomedical applications
    • Abstract:
    • 5.1 Introduction
    • 5.2 Application of silk sericin in the biomedical field
    • 5.3 Electrospinning
    • 5.4 Silk sericin nanofibers from electrospinning
    • 5.5 Molecular structure and physical properties
    • 5.6 Silk sericin/silk fibroin blend nanofibers by electrospinning
    • 5.7 Conclusion and future trends
  • Chapter 6: Silk fibroin microfiber and nanofiber scaffolds for tissue engineering and regeneration
    • Abstract:
    • 6.1 Introduction
    • 6.2 Silk fibroin (SF) microfibers for skin and connective tissue regeneration
    • 6.3 Formic acid (FA)-cross-linked 3-D SF microfiber-based nonwovens
    • 6.4 SF microfiber-based carded-needled 3-D nonwovens
    • 6.5 Nanofibers from electrospinning and tissue engineering
    • 6.6 Electrospun SF tubes for small calibre blood vessel regeneration
  • Chapter 7: Silk powder for regenerative medicine
    • Abstract:
    • 7.1 Introduction
    • 7.2 Silk particle production by the bottom up approach
    • 7.3 Silk powder production by the top down approach (milling)
    • 7.4 Characterisation of silk powder
    • 7.5 Applications of silk particles
    • 7.6 Conclusion
• Part II: Properties and behaviour of silk biomaterials
  • Chapter 8: Biochemical and biophysical properties of native Bombyx mori silk for tissue engineering applications
    • Abstract:
    • 8.1 Introduction
    • 8.2 Genetic sequence and primary structure of silk proteins
    • 8.3 Structure and assembly of native silk fibroin
    • 8.4 Physical and chemical properties of native silk fibroin fibers
    • 8.5 Conclusion
  • Chapter 9: Structure and properties of spider and silkworm silk for tissue scaffolds
    • Abstract:
    • 9.1 Introduction
    • 9.2 Microstructure of silks
    • 9.3 Mechanical

Product details

• Authors: Subhas Kundu, Subhas (EDT) Kundu, Subhas (Indian Institute of Technology Khar Kundu, Subhas C. (European Research Area Chair and Kundu, Subhas C. (Research Coordinator and Former Kundu
• Assisted by: Subhas Kundu (Editor), Subhas C Kundu (Editor), Subhas C. Kundu (Editor), Subhas C. Kundu (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 18.03.2014
• EAN: 9780857096999
• ISBN: 978-0-85709-699-9
• No. of pages: 582
• Series: Woodhead Publishing Series in Biomaterials; Woodhead Publishing; Woodhead Publishing; Woodhead Publishing Series in Biomaterials; Woodhead Publishing Biomateria
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; SCIENCE / Biotechnology, biotechnology