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Over the past decade significant advances in technology have opened up the field of glycobiology. In particular, improved methods for carbohydrate analysis have led to important biochemical observations demonstrating that sugars play crucial roles in human physiology. It is clear that many diseases are associated with characteristic changes in glycosylation and furthermore, the possibility of modulating glycan processing to treat disease is beginning to be realised. This volume summarises some of the important recent developments in "glycobiology and medicine. " We highlighted some of the numerous areas in which there are glycosylation dependant pathological mechanisms causing common diseases. The next decade will undoubtedly see novel diagnostic and therapeutic techniques originating from these observations. This will significantly enhance our ability to combat infection and diseases such as bacterial and viral infections, some cancers, glycolipid storage disorders, systemic autoimmune disease and disorders that involve cytokine related inflammatory mechanisms. These topics were discussed at the 6th Jenner Glycobiology and Medicine meeting. This meeting received a European Commission Education grant (No. HPCF-2002-00250). CONTENTS Glycosylation Dependent Bacterial Infections 1. A Sweet Coating-How Bacteria Deal with Sugars . . . . . . . . . . . . . . . . . . . . . 3 Anthony P. Corfield, Rebecca Wiggins, Cathryn Edwards, Neil Myerscough, Bryan F. Warren, Peter Soothill, Michael R. Millar, and Patrick Horner 2. The Glycosylation of Airway Mucins in Cystic Fibrosis and Its Relationship with Lung Infection by Pseudomonas aeruginosa . . . . . . . . . . . 17 . Philippe Roussel and Genevieve Lamblin 3. Structural Basis for Bacterial Adhesion in the Urinary Tract. . . . . . . . . . . . . 33 . . Jenny Berglund and Stefan D.
List of contents
Glycosylation Dependent Bacterial Infections.- 1. A Sweet Coating-How Bacteria Deal with Sugars.- 2. The Glycosylation of Airway Mucins in Cystic Fibrosis and Its Relationship with Lung Infection by Pseudomonas aeruginosa.- 3. Structural Basis for Bacterial Adhesion in the Urinary Tract.- Glycosylation Dependent Viral Infections.- 4. Crystal Structure of an Intact Human IgG: Antibody Asymmetry, Flexibility, and a Guide for HIV-1 Vaccine Design.- Inflammation.- 5. Remnant Epitopes Generate Autoimmunity: From Rheumatoid Arthritis and Multiple Sclerosis to Diabetes.- 6. Endothelial Cell Glycosylation: Regulation and Modulation of Biological Processes.- 7. Involvement of GAGs in the Activity of Pro-inflammatory Factors.- 8. Lectin Domains on Cytokines.- 9. Cytokines and Glycosaminoglycans (GAGs).- Glycopathology.- 10. Thomsen-Friedenreich Antigen: The "Hidden" Tumor Antigen.- 11. Glycodynamics of Mucin Biosynthesis in Gastrointestinal Tumor Cells.- 12. O-GlcNAc Glycosylation and Neurological Disorders.- Congenital Defects in Glycosylation.- 13. The Carbohydrate Epitope of the Neutralizing anti-HIV-1 Antibody 2G12.- 14. New Therapeutics for the Treatment of Glycosphingolipid Lysosomal Storage Diseases.- Glycoimmunology.- 15. The Mannose-Binding Lectin (MBL) Route for Activation of Complement.- 16. Anti-inflammatory Properties of Specific Glycoforms of Human ?1 Acid Glycoprotein.- 17. The Glycosylation of Tyrosinase in Melanoma Cells and the Effect on Antigen Presentation.- 18. Glycobiology of the Rheumatic Diseases: An Update.
