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How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodeling process. In the final section, a new approach to protection against ischemia/reperfusion damage is presented.
List of contents
I: Modulators of Ischemia/Reperfusion Damage: H+, Na+, and Ca2+.- Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues.- Role of the Vacuolar Proton Pump in Preconditioning.- Role of the Na+/Ca2+ Exchanger in Intracellular Ca2+ Overload During Ischemia and Reperfusion.- The Role of Sodium-Hydrogen Exchange in the Ischemic and Reperfused Myocardium.- II: Modulators of Ischemia/Reperfusion Damage: Lipid Metabolites.- Effects of Lysophosphoglycerides on KATP Channels in Cardiac Ventricular Cells: Blockage or Run-down?.- Lysophosphatidylcholine: A Possible Modulator of Ischemic Injury in the Heart.- Potential Role of Phospholipase A2 in the Normoxic, Ischemic, and Reperfused Heart.- Effects of Lysophosphatidylcholine on Ion Transporters in the Heart.- III: Molecular Mechanisms of Myocardial and Vascular Remodeling in the Ischemic Heart.- Molecular Mechanism of Cardiovascular Remodeling.- Osteopontin as a Coordinator of Stress-Induced Host Responses: Molecular Analysis of Its Interaction with Various Ligands.- Coronary Reperfusion and Cytokines.- Brief Ischemia/Reperfusion Activates Transcellular Signaling Cascades and Leads to Proto-Oncogene Expression and Growth Factor Production.- IV: New Therapeutic Strategy to Attenuate Ischemia/Reperfusion Damage.- Ischemia/Reperfusion Injury and Ion Channel Blockade.- Energy Ameliorants: A New Category of Antianginal Drugs.- Strategy Toward Warm Heart Cardioplegia: Our Experimental and Clinical Experience.
