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Since the 1st Yamaguchi Symposium on Liver Diseases in 1989, this series of symposia has provided opportunities for exchanges of information on the topic between leading Japanese hepatologists and internationally renowned scientists. Somewhat unusually for meetings held in Japan, the official language of the symposium is English. The pro ceedings of these symposia are published under the title Frontiers in Hepatology and distributed worldwide. The 12th symposium was held on December 9 and 10,2000, at the ANA Hotel, Ube, Japan. The theme selected by the Organizing Committee was "Growth, Proliferation, and Apoptosis in Hepatocytes;' each of which is important in the understanding of the pathophysiology of intractable liver disease. Nine Japanese hepatologists were invited to give presentations, as was leading u.S. researcher Professor D.A. Brenner, recently elected editor-in-chief of the journal Gastroenterology. The reports given at the two-day meeting were valuable in furthering our under standing of the complicated signaling system involved in hepatocyte differentiation, proliferation, and apoptosis. Progress in this field is rapid, and another symposium on the same theme will be held in the near future. We believe that these proceedings are useful in summarizing current information on this important topic. The Organizing Committee would like to express special thanks to all participants and to the Viral Hepatitis Research Foundation of Japan for its continuing financial support.
List of contents
HHM: A Dominant Inhibitory Helix-Loop-Helix Protein Associated with Liver-Specific Gene Expression and Liver Stern Cells.- Expression of Musashi-1 Antigen, A Neural Stern Cell RNA-Binding Protein, in the Liver Tissues of Patients with Hepatitis.- Reconstitution of Hepatic Tissues Using Liver Stem Cells.- Regulation of TNF-?- and Fas-Induced Hepatic Apoptosis by NF-?B.- Retinoid-Induced Apoptosis in Hepatocellular Carcinoma: A Molecular Basis for "Clonal Deletion" Therapy.- Signal Transduction Involved in Cell Cycle Regulation of Normal Hepatocyte and Hepatoma Cells.- Effects of Simultaneous Treatment with Growth Factors on DNA Synthesis, MAPK Activity, and G1 Cyclins in Rat Hepatocytes.- Involvement of p21WAF1/CIP1 and p27KIP1 in Troglitazone-Induced Cell Cycle Arrest in Human Hepatoma Cell Lines.- Role of Fas Ligand in Immunopathogenesis of Hepatocellular Carcinoma.- Induction of Proliferation-Related Signals by Hepatitis C Virus.
Summary
Since the 1st Yamaguchi Symposium on Liver Diseases in 1989, this series of symposia has provided opportunities for exchanges of information on the topic between leading Japanese hepatologists and internationally renowned scientists. Somewhat unusually for meetings held in Japan, the official language of the symposium is English. The pro ceedings of these symposia are published under the title Frontiers in Hepatology and distributed worldwide. The 12th symposium was held on December 9 and 10,2000, at the ANA Hotel, Ube, Japan. The theme selected by the Organizing Committee was "Growth, Proliferation, and Apoptosis in Hepatocytes;' each of which is important in the understanding of the pathophysiology of intractable liver disease. Nine Japanese hepatologists were invited to give presentations, as was leading u.S. researcher Professor D.A. Brenner, recently elected editor-in-chief of the journal Gastroenterology. The reports given at the two-day meeting were valuable in furthering our under standing of the complicated signaling system involved in hepatocyte differentiation, proliferation, and apoptosis. Progress in this field is rapid, and another symposium on the same theme will be held in the near future. We believe that these proceedings are useful in summarizing current information on this important topic. The Organizing Committee would like to express special thanks to all participants and to the Viral Hepatitis Research Foundation of Japan for its continuing financial support.
