Unfolded Protein Response and Cellular Stress, Part C

Informationen zum Autor P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups. Klappentext The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and p...

List of contents

Section I: New Approaches to Studying UPR and Cell Stress

1. CFTR Expression Regulation by the Unfolded Protein Response
   Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok
2. GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy
   Thomas C. Chen
3. Targeting the Unfolded Protein Response in Cancer Therapy
   Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan
4. Large-scale analysis of UPR-mediated apoptosis in human cells
   Andrew M. Fribley, Justin R. Miller, Tyler E. Reist¹, Michael U. Callaghan and Randal J. Kaufman
5. Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry
   Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur
6. Animal models in the study of the unfolded protein response
   Hemamalini Bommiasamy and Brian Popko
7. Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase
   Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett
8. Analysis of nelfinavir-induced endoplasmic reticulum stress
   Ansgar Brüning
9. Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo
   Alexander Gow
10. Glycoprotein maturation and the UPR
    Andreas J. Hülsmeier, Michael Welti and Thierry Hennet
11. Monitoring and Manipulating Mammalian Unfolded Protein Response
    Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin
12. A screen for mutants requiring activation of the unfolded protein response for viability
    Guillaume Thibault and Davis T.W. Ng
13. Signalling Pathways of Proteostasis Network Unrevealed By Proteomic Approaches on The Understanding of Misfolded Protein Rescue
    Patrícia Gomes-Alves, Sofia Neves and Deborah Penque
14. Decreased Secretion and Unfolded Protein Response Up-Regulation
    Carissa L. Young, Theresa Yuraszeck, Anne S. Robinson
15. Measuring signaling by the unfolded protein response
    David Cox, Natalie Strudwick, Ahmed A. Ali, Adrienne W. Paton, James C. Paton, and Martin Schröder
16. Unfolded Protein Response
    Jie Shang
17. Regulation of immunoglobulin synthesis, modification and trafficking by the unfolded protein response: a quantitative approach
    Adi Drori and Boaz Tirosh
18. Use of Chemical Genomics in Assessment of the UPR
    Sakae Saito, Akihiro Tomida
19. Small GTPase signalling and the Unfolded Protein Response
    Marion Bouchecareilh, Esther Marza, Marie-Elaine Caruso and Eric Chevet
20. Inhibitors of advanced glycation and endoplasmic reticulum stress
    Reiko Inagi

Product details

• Authors: P. Michael Conn
• Assisted by: P. Michael Conn (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 12.04.2011
• EAN: 9780123859280
• ISBN: 978-0-12-385928-0
• No. of pages: 464
• Series: Academic Press; Methods in Enzymology; Academic Press; Methods in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Cytology, MEDICAL / Biochemistry