Unfolded Protein Response and Cellular Stress, Part a

Informationen zum Autor P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups. Klappentext The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and p...

List of contents

Section I: UPR and Cell Stress in Normal and Diseased Cells

1. The Unfolded Protein Response in Mouse Cerebral Cortex
   Nirinjini Naidoo
2. Immunohistochemical Detection of the Unfolded Protein Response in Atherosclerotic Plaques
   Sárka Lhoták and Richard C. Austin
3. The role of PDI as a survival factor in cardiomyocyte ischemia
   Stefano Toldo; Anna Severino; Antonio Abbate; Alfonso Baldi
4. Measurement of the Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
   Guenther Boden and Salim Merali
5. Measurement of the unfolded protein response (UPR) in monocytes
   Tomás P. Carroll, Catherine M. Greene, and Noel G. McElvaney
6. Assessment of Endurance Exercise Training in Hepatic Endoplasmic Reticulum (ER) Stress
   Natalie Ann Chapados
7. Discovery approaches to UPR in athero - susceptible endothelium in vivo
   Mete Civelek, Elisabetta Manduchi, Gregory Grant, Christian J. Stoeckert Jr, Peter F. Davies
8. Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells
   Ines Witte & Sven Horke
9. Measuring the impact of cigarette smoke on the UPR
   Hong Zhao, Jin Yang, Lin Shan and Ellen D. Jorgensen
10. Induction and measurement of UPR and osmotic stress in the yeast Pichia pastoris
    Martin Dragosits, Diethard Mattanovich and Brigitte Gasser
11. Induction of ER stress response leading to programmed cell death in Trypanosoma brucei
    Hanoch Goldshmidt and Shulamit Michaeli
12. Measurement of Activation of the Endoplasmic Reticulum Stress Response in Autoimmune Myositis
    Heather M. Alger, Sree Rayavarapu and Kanneboyina Nagaraju
13. Activation of the unfolded protein response in human acute myeloid leukemia
    Julian A. Schardt , Beatrice U. Mueller and Thomas Pabst
14. Modulation of the Unfolded Protein Response by GRP78 in Prostate Cancer
    Gustaaf de Ridder, Rupa Ray, Uma K. Misra and Salvatore V. Pizzo
15. Endoplasmic Reticulum Stress In Brain Damage
    Ram Raghubir, Venkata Prasuja Nakka, and Suresh L. Mehta
16. Methods and Models for Monitoring UPR associated Macrophage Death during Advanced Atherosclerosis
    Edward B. Thorp
17. Detecting Autophagy in Response to ER Stress Signals in Cancer
    Guillermo Velasco, María Salazar, Sonia Hernández-Tiedra, Sofía Torres, Mar Lorente, Manuel Guzmán
18. The Unfolded Protein Response Induced By Salt Stress in Arabidopsis
    Miaoying Wang, Qiangyi Xu, and Ming Yuan
19. Measurement of ER Stress Response and Inflammation in the Mouse Model of Non-alcoholic Fatty Liver Disease
    Ze Zheng , Chunbin Zhang, Kezhong Zhang

Product details

• Authors: P. Michael Conn
• Assisted by: Dr. P. Michael Conn (Editor), P Michael Conn (Editor), P. Michael Conn (Editor), P. Michael (Senior Vice President for Research and Associate Provost Conn (Editor), P. Michael (Texas Tech University Health Sciences Center Conn (Editor), Saurabh Jha (Editor), P. Michael Conn (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 24.03.2011
• EAN: 9780123851161
• ISBN: 978-0-12-385116-1
• No. of pages: 432
• Series: Academic Press; Methods in Enzymology; Methods in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Cytology, MEDICAL / Biochemistry