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Presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. This title elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules.
List of contents
- Measurement and Analysis of Equilibrium Binding Titrations: A beginner's guide
Dorothy Beckett
- Macromolecular Competition Titration Method: Accessing Thermodynamics of the Unmodified Macromolecule - Ligand Interactions Through Spectroscopic Titrations of Fluorescent Analogs
Wlodzimierz Bujalowski and Maria J. Jezewska
- Analysis of PKR-RNA interactions by sedimentation velocity
C. Jason Wong, Katherine Launer-Felty and James L. Cole
- Structural and Thermodynamic Analysis of PDZ/Ligand Interactions
Tyson R. Shepherd and Ernesto J. Fuentes
- Thermodynamic analysis of metal ion-induced protein assembly
Andrew B. Herr and Deborah G. Conrady
- Thermodynamic Dissection of Colicin Interactions
Nicholas G Housden and Colin Kleanthous
- Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling
John E. Ladbury and Stefan T. Arold
- Structural and Functional Energetic Linkages in Allosteric Regulation of Muscle Pyruvate Kinase
J. Ching Lee and Petr Herman
- Analysis of Free Energy versus Temperature Curves in Protein Folding and Macromolecular Interactions
Vince J. LiCata and Chin-Chi Liu
- Application of the Sequential n-Step Kinetic Mechanism to Polypeptide Translocases
Aaron L. Lucius, Justin M. Miller and Burki Rajendar
- A Coupled Equilibrium Approach to Study Nucleosome Thermodynamics
Andrew J. Andrews and Karolin Luger
- Quantitative methods for measuring DNA flexibility in vitro and in vivo
Justin P. Peters, Nicole Becker, Emily M. Rueter, Zeljko Bajzer, Jason D. Kahna and L. James Maher
- A Thermodynamic Approach for the Targeting of Nucleic Acid Structures Using Their Complementary Single Strands
Hui-Ting Lee, Caroline Carr, Hollie Siebler, Lela Waters, Irine Khutsishvili, Fany Iseka, Brian Domack, Chris M. Olsen, and Luis Marky
- Thermodynamics of Biological Processes
Hernan G. Garcia, Jane Kondev, Nigel Orme, Julie Theriot and Rob Phillips
- Protein stability in the presence of co-solutes
Luis Marcelo F. Holthauzen, Matthew Auton, Mikhail Sineva and Jorg Rosgen
- Small Angle X-ray Scattering Studies of Peptide-Lipid Interactions using the Mouse Paneth Cell ?-Defensin Cryptdin-4
Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette and Gerard C. L. Wong
- Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery
Rebecca Strawn, Thomas Stockner, Milan Melichercik, Lihua Jin, Wei-Feng Xue, Jannette Carey and Rüdiger Ettrich
- Using tryptophan fluorescence to measure the stability of membrane proteins folded in liposomes
C. Preston Moon1 and Karen G. Fleming
- Non-B Conformations of CAG Repeats Using 2-aminopurine
Natalya N. Degtyareva and Jeffrey T. Petty
- Disulfide bond-mediated passenger domain stalling as a structural probe of autotransporter outer membrane secretion in vivo
Jonathan P. Renn & Patricia L. Clark
- Strategies for the Thermodynamic Characterization of Linked Binding/Local Folding Reactions Within the Native State: Application to the LID Domain of Adenylate Kinase from Escherichia coli
Travis P. Schrank, W. Austin Elam, Jing Li and Vincent J. Hilser
