Arrestins - Pharmacology and Therapeutic Potential

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

List of contents

Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.

Summary

This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.

Product details

• Assisted by: Vsevolod V. Gurevich (Editor), Vsevolo V Gurevich (Editor), Vsevolod V Gurevich (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 28.08.2013
• EAN: 9783642411984
• ISBN: 978-3-642-41198-4
• No. of pages: 447
• Dimensions: 166 mm x 23 mm x 243 mm
• Weight: 872 g
• Illustrations: VIII, 447 p. 53 illus., 42 illus. in color.
• Series: Handbook of Experimental Pharmacology; Handbook of Experimental Pharmacology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; B, Life Sciences, PHYSIOLOGY, biochemistry, Pharmacology, proteins, Biomedical and Life Sciences, Medical Genetics, Cellular biology (cytology), Biochemistry, general, Pharmacology/Toxicology, Gene Therapy, Cell Physiology, Protein Structure, Receptors