Read more
Informationen zum Autor Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Klappentext This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented. Zusammenfassung Inhibitors of protein lipidation have been shown to be useful as anticancer drugs. This work summarizes the developments regarding enzymes responsible for protein lipidation. It also presents three-dimensional structures of protein farnesytransferase! protein geranylgeranytransferase II! and n-myristoryltransferase. Inhaltsverzeichnis Mechanism of Catalysis by Protein Farnesyltransferase Structure of Protein Farnesyltransferase Mutational Analyses of Protein Farnesyltransferase Farnesyltransferase Inhibitors Protein Geranylgeranyltransferase Type I Biochemistry of Rab Geranylgeranyltransferase Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase Reversible Modification of Proteins with Thioester-Linked Fatty Acids Biology and Enzymology of Protein N-Myristoylation
List of contents
Mechanism of Catalysis by Protein Farnesyltransferase
Structure of Protein Farnesyltransferase
Mutational Analyses of Protein Farnesyltransferase
Farnesyltransferase Inhibitors
Protein Geranylgeranyltransferase Type I
Biochemistry of Rab Geranylgeranyltransferase
Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase
Reversible Modification of Proteins with Thioester-Linked Fatty Acids
Biology and Enzymology of Protein N-Myristoylation
