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What are the different muscarinic acetylcholine receptor subtypes andhow are they distributed in the airways and molecular signallingmechanisms? What is their function in neurogenic and non-neurogeniccontrol of the airways and in inflammatory mechanisms? How is their geneexpression regulated? The great importance of muscarinic acetylcholinereceptors for the pathophysiology and treatment of chronic inflammatoryobstructive airways diseases calls for a comprehensive and integratedoverview of the current knowledge to address such questions, to discussthe role of these receptor subtypes in diseases such as asthma and COPD,and to present novel perspectives on antimuscarinic drug development.The present book is the worthy result of this need. It points outinnovative insights into the hitherto poorly understood role ofpostjunctional muscarinic M2 receptors in airway smooth musclecontraction and sheds some light on the novel concepts of antimuscarinicdrug development, with special reference to the l
List of contents
Cholinergic and noncholinergic parasympathetic control of airway smooth muscle.- Role of non-neuronal and neuronal acetylcholine in the airways.- Identification, localization and function of muscarinic receptor subtypes in the airways.- Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle.- Dysfunction of prejunctional muscarinic M2 receptors: role of environmental factors.- Muscarinic receptor-?-adrenoceptor cross-talk in airway smooth muscle.- Gene regulation of muscarinic receptor subtypes.- Muscarinic control of airway mucus secretion.- The role of anticholinergics in asthma and COPD.- Novel perspectives in anticholinergic therapy.
Summary
What are the different muscarinic acetylcholine receptor subtypes and
how are they distributed in the airways and molecular signalling
mechanisms? What is their function in neurogenic and non-neurogenic
control of the airways and in inflammatory mechanisms? How is their gene
expression regulated? The great importance of muscarinic acetylcholine
receptors for the pathophysiology and treatment of chronic inflammatory
obstructive airways diseases calls for a comprehensive and integrated
overview of the current knowledge to address such questions, to discuss
the role of these receptor subtypes in diseases such as asthma and COPD,
and to present novel perspectives on antimuscarinic drug development.
The present book is the worthy result of this need. It points out
innovative insights into the hitherto poorly understood role of
postjunctional muscarinic M2 receptors in airway smooth muscle
contraction and sheds some light on the novel concepts of antimuscarinic
drug development, with special reference to the l
